Phenol, 3,5-dimethyl-4-(2-propynyloxy)- (9CI)

Base Information

• Chemical Name: Phenol, 3,5-dimethyl-4-(2-propynyloxy)- (9CI)
• CAS No.: 750624-43-2
• Molecular Formula: C11H12 O2
• Molecular Weight: 176.215
• Mol file: 750624-43-2.mol

Synonyms:Phenol,3,5-dimethyl-4-(2-propynyloxy)- (9CI)

Chemical Property of Phenol, 3,5-dimethyl-4-(2-propynyloxy)- (9CI)

Chemical Property:

• PSA: 29.46000
• LogP: 2.02100

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 3,5-dimethyl-4-(2-propynyloxy)- (9CI)

There total 2 articles about Phenol, 3,5-dimethyl-4-(2-propynyloxy)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1,3-dimethyl-2,5-bis-prop-2-ynyloxy-benzene (750624-36-3) → 1,4-dihydroxy-2,6-dimethylbenzene (654-42-2) + 3,5-dimethyl-4-prop-2-ynyloxy-phenol (750624-43-2)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/ol0489898

Reference yield:

1,4-dihydroxy-2,6-dimethylbenzene (654-42-2) → 3,5-dimethyl-4-prop-2-ynyloxy-phenol (750624-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / K₂CO₃ / dimethylformamide; toluene / 80 °C

2: 55 percent / BBr₃ / CH₂Cl₂ / 0.5 h / 20 °C

With boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ol0489898

Reference yield: 86.0%

allyl bromide (106-95-6) + 3,5-dimethyl-4-prop-2-ynyloxy-phenol (750624-43-2) → 5-allyloxy-1,3-dimethyl-2-prop-2-ynyloxy-benzene (750624-45-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h;

DOI:10.1021/ol0489898

upstream raw materials:

1,3-dimethyl-2,5-bis-prop-2-ynyloxy-benzene

1,4-dihydroxy-2,6-dimethylbenzene

Downstream raw materials:

5-allyloxy-1,3-dimethyl-2-prop-2-ynyloxy-benzene

5-methoxy-1,3-dimethyl-2-prop-2-ynyloxy-benzene

4-methoxy-2,6-dimethylphenol

Refernces