methyl 3-{5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-1,2,3,4-tetrahydro-isoquinolin-8-yl}-propionate

Base Information

Chemical Name:methyl 3-{5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-1,2,3,4-tetrahydro-isoquinolin-8-yl}-propionate
CAS No.:918411-13-9
Molecular Formula:C₂₅H₂₈N₂O₄
Molecular Weight:420.508
Hs Code.:

Synonyms:methyl 3-{5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-1,2,3,4-tetrahydro-isoquinolin-8-yl}-propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 3-{5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-1,2,3,4-tetrahydro-isoquinolin-8-yl}-propionate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 3-{5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-1,2,3,4-tetrahydro-isoquinolin-8-yl}-propionate

There total 8 articles about methyl 3-{5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-1,2,3,4-tetrahydro-isoquinolin-8-yl}-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 497068-68-5
tert-butyl 8-bromo-5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 918411-13-9
methyl 3-{5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-1,2,3,4-tetrahydro-isoquinolin-8-yl}-propionate

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / acetone

2: Pd(OAc)2 / various solvent(s)

3: H₂ / Pd/C / ethanol

4: Cs₂CO₃ / dimethylformamide

5: CF₃CO₂H

With palladium diacetate; hydrogen; potassium carbonate; caesium carbonate; trifluoroacetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; acetone; 2: Heck coupling;
DOI:10.1016/j.bmcl.2006.09.028

Reference yield:

: 853074-91-6
tert-butyl 5-(benzyloxy)-8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 918411-13-9
methyl 3-{5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-1,2,3,4-tetrahydro-isoquinolin-8-yl}-propionate

Guidance literature:: Multi-step reaction with 4 steps

1: Pd(OAc)2 / various solvent(s)

2: H₂ / Pd/C / ethanol

3: Cs₂CO₃ / dimethylformamide

4: CF₃CO₂H

With palladium diacetate; hydrogen; caesium carbonate; trifluoroacetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; 1: Heck coupling;
DOI:10.1016/j.bmcl.2006.09.028

Reference yield:

: 5-benzyloxy-8-(2-methoxycarbonyl-vinyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 918411-13-9
methyl 3-{5-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-1,2,3,4-tetrahydro-isoquinolin-8-yl}-propionate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethanol

2: Cs₂CO₃ / dimethylformamide

3: CF₃CO₂H

With hydrogen; caesium carbonate; trifluoroacetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.09.028