Technology Process of (2S,3S)-2-(3,4-dimethoxyphenyl)-4-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-5-methoxy-2,3-dihydrobenzofuran-3-carboxylic acid
There total 9 articles about (2S,3S)-2-(3,4-dimethoxyphenyl)-4-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-5-methoxy-2,3-dihydrobenzofuran-3-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(2S,3S)-N-acetyl-2-amino-3-methylpentanoic acid; oxygen; palladium diacetate; potassium hydrogencarbonate;
In
tert-Amyl alcohol;
at 100 ℃;
for 48h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/ja401731d
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate] / 50 °C / Inert atmosphere
2: hydrogenchloride / ethanol / 0 - 20 °C / Inert atmosphere
3: [bis(acetoxy)iodo]benzene; lithium carbonate; palladium diacetate / Hexafluorobenzene / 24 h / 100 °C
4: sodium hydroxide; water / methanol; tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
5: palladium diacetate; (2S,3S)-N-acetyl-2-amino-3-methylpentanoic acid; potassium hydrogencarbonate; oxygen / tert-Amyl alcohol / 48 h / 100 °C / Schlenk technique; Inert atmosphere
With
hydrogenchloride; (2S,3S)-N-acetyl-2-amino-3-methylpentanoic acid; [bis(acetoxy)iodo]benzene; dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate]; water; oxygen; palladium diacetate; lithium carbonate; potassium hydrogencarbonate; sodium hydroxide;
In
tetrahydrofuran; methanol; tert-Amyl alcohol; Hexafluorobenzene; ethanol;
DOI:10.1021/ja401731d
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate] / 50 °C / Inert atmosphere
2: hydrogenchloride / ethanol / 0 - 20 °C / Inert atmosphere
3: [bis(acetoxy)iodo]benzene; lithium carbonate; palladium diacetate / Hexafluorobenzene / 24 h / 100 °C
4: sodium hydroxide; water / methanol; tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
5: palladium diacetate; (2S,3S)-N-acetyl-2-amino-3-methylpentanoic acid; potassium hydrogencarbonate; oxygen / tert-Amyl alcohol / 48 h / 100 °C / Schlenk technique; Inert atmosphere
With
hydrogenchloride; (2S,3S)-N-acetyl-2-amino-3-methylpentanoic acid; [bis(acetoxy)iodo]benzene; dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate]; water; oxygen; palladium diacetate; lithium carbonate; potassium hydrogencarbonate; sodium hydroxide;
In
tetrahydrofuran; methanol; tert-Amyl alcohol; Hexafluorobenzene; ethanol;
DOI:10.1021/ja401731d
