tert-butyl {4-[((2S)-2-{[N-(biphenyl-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

Base Information

Chemical Name:tert-butyl {4-[((2S)-2-{[N-(biphenyl-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate
CAS No.:757975-87-4
Molecular Formula:C₃₄H₄₅N₃O₄
Molecular Weight:559.749
Hs Code.:

Synonyms:tert-butyl {4-[((2S)-2-{[N-(biphenyl-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

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Chemical Property of tert-butyl {4-[((2S)-2-{[N-(biphenyl-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

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Technology Process of tert-butyl {4-[((2S)-2-{[N-(biphenyl-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

There total 11 articles about tert-butyl {4-[((2S)-2-{[N-(biphenyl-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 757976-48-0
N²-(biphenyl-3-yl)-N-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)-N²-(biphenyl-3-yl)-L-leucinamide

: 5292-43-3
bromoacetic acid tert-butyl ester

: 757975-87-4
tert-butyl {4-[((2S)-2-{[N-(biphenyl-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.12.053

Reference yield:

: 882296-91-5
(1-{[(4-benzyloxy-phenyl)-(2-nitro-benzenesulfonyl)-amino]-methyl}-propyl)-carbamic acid tert-butyl ester

: 757975-87-4
tert-butyl {4-[((2S)-2-{[N-(biphenyl-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: PhSH; K₂CO₃ / acetonitrile / 20 °C

2.1: trifluoroacetic acid / CH₂Cl₂

2.2: 99 percent / 1-hydroxybenzotriazole; 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl / dimethylformamide

3.1: 87 percent / H₂ / Pd-C / ethanol / 6 h / 40 °C

4.1: 81 percent / NaH / tetrahydrofuran; dimethylformamide / 1.5 h / 20 °C

With hydrogen; sodium hydride; potassium carbonate; thiophenol; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2.2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.06.032

Reference yield:

: 757976-17-3
N-(biphenyl-3-yl)-L-leucine

: 757975-87-4
tert-butyl {4-[((2S)-2-{[N-(biphenyl-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / CH₂Cl₂

1.2: 99 percent / 1-hydroxybenzotriazole; 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl / dimethylformamide

2.1: 87 percent / H₂ / Pd-C / ethanol / 6 h / 40 °C

3.1: 81 percent / NaH / tetrahydrofuran; dimethylformamide / 1.5 h / 20 °C

With hydrogen; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.06.032