Technology Process of (R,S)-(2Z,4E)-3-methyl-5-(6-<13CD3>-2,6,6-trimethylcyclohex-1-en-1-yl)-2,4-pentadienenal
There total 6 articles about (R,S)-(2Z,4E)-3-methyl-5-(6-<13CD3>-2,6,6-trimethylcyclohex-1-en-1-yl)-2,4-pentadienenal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C
2: 98 percent / DIBAL / tetrahydrofuran / 0.25 h / -78 °C
3: 86 percent / aq. HCl / 1,2-dichloro-ethane / 1 h / 55 °C
With
hydrogenchloride; diisobutylaluminium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1002/jlcr.2580360807
- Guidance literature:
-
Multi-step reaction with 5 steps
1: aq. HCl / ethanol / 4 h / 82 °C
2: 1.) n-BuLi, TMEDA / 1.) hexane, a) -78 deg C, 30 min, b) RT, 4 h, 2.) hexane, RT, 12 h
3: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C
4: 98 percent / DIBAL / tetrahydrofuran / 0.25 h / -78 °C
5: 86 percent / aq. HCl / 1,2-dichloro-ethane / 1 h / 55 °C
With
hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisobutylaluminium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; 1,2-dichloro-ethane;
DOI:10.1002/jlcr.2580360807
