1-(4-bromophenyl)-2-(2-dimethyl(oxo)-λ⁶-sulfanylidene)ethan-1-one

Base Information

• Chemical Name: 1-(4-bromophenyl)-2-(2-dimethyl(oxo)-λ⁶-sulfanylidene)ethan-1-one
• CAS No.: 1179348-62-9
• Molecular Formula: C₁₀H₁₁BrO₂S
• Molecular Weight: 275.166
• Mol file: 1179348-62-9.mol

Synonyms:1-(4-bromophenyl)-2-(2-dimethyl(oxo)-λ⁶-sulfanylidene)ethan-1-one

Chemical Property of 1-(4-bromophenyl)-2-(2-dimethyl(oxo)-λ⁶-sulfanylidene)ethan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-bromophenyl)-2-(2-dimethyl(oxo)-λ⁶-sulfanylidene)ethan-1-one

There total 6 articles about 1-(4-bromophenyl)-2-(2-dimethyl(oxo)-λ⁶-sulfanylidene)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

trimethylsulfoxonium iodide (1774-47-6) + 4-chlorobenzoyl chloride (586-75-4) → 1-(4-bromophenyl)-2-(2-dimethyl(oxo)-λ6-sulfanylidene)ethan-1-one (1179348-62-9)

Guidance literature:

trimethylsulfoxonium iodide; With potassium tert-butylate; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

4-chlorobenzoyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00085

Reference yield: 87.0%

tert-butyl (4-bromobenzoyl)(phenyl)carbamate + trimethylsulfoxonium iodide (1774-47-6) → 1-(4-bromophenyl)-2-(2-dimethyl(oxo)-λ6-sulfanylidene)ethan-1-one (1179348-62-9)

Guidance literature:

trimethylsulfoxonium iodide; With potassium tert-butylate; In tetrahydrofuran; at 65 ℃; for 2h; Schlenk technique; Inert atmosphere;

tert-butyl (4-bromobenzoyl)(phenyl)carbamate; In tetrahydrofuran; at 23 ℃; for 15h; Schlenk technique; Inert atmosphere; Cooling with ice;

DOI:10.1021/acs.orglett.1c01535

Reference yield: 82.0%

4-methoxycarbonylphenyl bromide (619-42-1) + trimethyl sulfoxonium chloride (5034-06-0) → 1-(4-bromophenyl)-2-(2-dimethyl(oxo)-λ6-sulfanylidene)ethan-1-one (1179348-62-9)

Guidance literature:

trimethyl sulfoxonium chloride; With potassium tert-butylate; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

4-methoxycarbonylphenyl bromide; In tetrahydrofuran; for 2h; Inert atmosphere;

DOI:10.1021/ol901298p

upstream raw materials:

4-methoxycarbonylphenyl bromide

trimethyl sulfoxonium chloride

trimethylsulfoxonium iodide

4-chlorobenzoyl chloride

Downstream raw materials:

1-(4-bromophenyl)-2-methoxyethan-1-one

1-(4-bromophenyl)-2-(phenylamino)ethanone

4-(4-bromophenyl)-1,2-diphenyl-1H-imidazole

tert-butyl-(2R,3R)-2,3-bis(4-bromobenzoyl)-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-carboxylate