[4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:[4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-(4-methylpiperazin-1-yl)methanone
CAS No.:863307-01-1
Molecular Formula:C₁₈H₁₈ClN₅O
Molecular Weight:355.827
Hs Code.:

Synonyms:[4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-(4-methylpiperazin-1-yl)methanone

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Chemical Property of [4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-(4-methylpiperazin-1-yl)methanone

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Technology Process of [4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-(4-methylpiperazin-1-yl)methanone

There total 8 articles about [4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 109-01-3
1-methyl-piperazine

: 863307-00-0
4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoic acid

: 863307-01-1
[4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-(4-methylpiperazin-1-yl)methanone

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

: 109-01-3
1-methyl-piperazine

: C₁₃H₇Cl₂N₃O

: 863307-01-1
[4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-(4-methylpiperazin-1-yl)methanone

Guidance literature:: With triethylamine; In tetrahydrofuran; water; at 0 - 20 ℃; for 1h;

Reference yield:

: 187724-93-2
4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoic acid ethyl ester

: 863307-01-1
[4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate; water / methanol / 16 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 50 °C / Inert atmosphere

3: triethylamine / tetrahydrofuran; water / 1 h / 0 - 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; water; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; water;
DOI:10.1021/acsmedchemlett.9b00317