ethyl 3-amino-5-thioxo-6-(2,4,6-trimethoxyphenyl)-8-(3,4,5-trimethoxyphenyl)-5H-pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidine-2-carboxylate

Base Information

Chemical Name:ethyl 3-amino-5-thioxo-6-(2,4,6-trimethoxyphenyl)-8-(3,4,5-trimethoxyphenyl)-5H-pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidine-2-carboxylate
CAS No.:1628222-52-5
Molecular Formula:C₃₀H₃₀N₄O₈S₂
Molecular Weight:638.722
Hs Code.:

Synonyms:ethyl 3-amino-5-thioxo-6-(2,4,6-trimethoxyphenyl)-8-(3,4,5-trimethoxyphenyl)-5H-pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidine-2-carboxylate

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Chemical Property of ethyl 3-amino-5-thioxo-6-(2,4,6-trimethoxyphenyl)-8-(3,4,5-trimethoxyphenyl)-5H-pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidine-2-carboxylate

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Technology Process of ethyl 3-amino-5-thioxo-6-(2,4,6-trimethoxyphenyl)-8-(3,4,5-trimethoxyphenyl)-5H-pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidine-2-carboxylate

There total 3 articles about ethyl 3-amino-5-thioxo-6-(2,4,6-trimethoxyphenyl)-8-(3,4,5-trimethoxyphenyl)-5H-pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 18964-26-6
ethyl chloro(cyano)acetate

: 1628222-49-0
5-(2,4,6-trimethoxyphenyl)-7-(3,4,5-trimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dithione

: 1628222-52-5
ethyl 3-amino-5-thioxo-6-(2,4,6-trimethoxyphenyl)-8-(3,4,5-trimethoxyphenyl)-5H-pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidine-2-carboxylate

Guidance literature:: 5-(2,4,6-trimethoxyphenyl)-7-(3,4,5-trimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dithione; With sodium methylate; In methanol; at 20 ℃; for 1h;

ethyl chloro(cyano)acetate; In methanol; for 5h; Heating;
DOI:10.1515/hc-2013-0199

Reference yield:

: 112742-11-7
2.4.6.3'.4'.5'-Hexamethoxy-chalkon

: 1628222-52-5
ethyl 3-amino-5-thioxo-6-(2,4,6-trimethoxyphenyl)-8-(3,4,5-trimethoxyphenyl)-5H-pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate / ethanol / 8 h / Heating

2.1: sodium hydrogencarbonate / ethanol; water / 2 h / Reflux

2.2: 2 h / Heating

3.1: sodium methylate / methanol / 1 h / 20 °C

3.2: 5 h / Heating

With ammonium acetate; sodium methylate; sodium hydrogencarbonate; In methanol; ethanol; water;
DOI:10.1515/hc-2013-0199

Reference yield:

: 1628222-41-2
2-amino-4-(2,4,6-trimethoxyphenyl)-6-(3,4,5-trimethoxyphenyl)nicotinonitrile

: 1628222-52-5
ethyl 3-amino-5-thioxo-6-(2,4,6-trimethoxyphenyl)-8-(3,4,5-trimethoxyphenyl)-5H-pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / ethanol; water / 2 h / Reflux

1.2: 2 h / Heating

2.1: sodium methylate / methanol / 1 h / 20 °C

2.2: 5 h / Heating

With sodium methylate; sodium hydrogencarbonate; In methanol; ethanol; water;
DOI:10.1515/hc-2013-0199