(S)-2-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid

Base Information

Chemical Name:(S)-2-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid
CAS No.:103321-30-8
Molecular Formula:C₃₂H₄₃N₁₁O₈
Molecular Weight:709.762
Hs Code.:

Synonyms:(S)-2-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid

Suppliers and Price of (S)-2-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid

There total 8 articles about (S)-2-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 103321-45-5
(S)-2-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid di-tert-butyl ester

: 103321-30-8
(S)-2-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid

Guidance literature:: With trifluoroacetic acid; for 0.166667h; Ambient temperature;
DOI:10.1021/jm00160a014

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 103321-30-8
(S)-2-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / diphenylphosphoryl azide (DPPA), Et₃N / dimethylformamide / Ambient temperature

2: 56 percent / CH₃COOH, H₂ / 5percent Pd/C / methanol / 2280 - 3040 Torr

3: 1.) diethyl phosphorocyanidate (DEPC), Et₃N / 1.) DMF, 2.) DMF, 3 days

4: 66 percent / CF₃COOH / 0.17 h / Ambient temperature

With diethyl cyanophosphonate; diphenylphosphoranyl azide; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00160a014

Reference yield:

: 103321-35-3
4-(4-Amino-butyrylamino)-butyric acid methyl ester; hydrochloride

: 103321-30-8
(S)-2-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / dimethylformamide / 0.5 h

2: 89 percent / Ba(OH)2.8H₂O / ethanol; H₂O / Ambient temperature

3: 99 percent / diphenylphosphoryl azide (DPPA), Et₃N / dimethylformamide / Ambient temperature

4: 56 percent / CH₃COOH, H₂ / 5percent Pd/C / methanol / 2280 - 3040 Torr

5: 1.) diethyl phosphorocyanidate (DEPC), Et₃N / 1.) DMF, 2.) DMF, 3 days

6: 66 percent / CF₃COOH / 0.17 h / Ambient temperature

With barium dihydroxide; diethyl cyanophosphonate; diphenylphosphoranyl azide; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00160a014