(R)-N-{1-methyl-2-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-piperidin-1-yl]-ethyl}-4-(2-phenoxy-phenylsulfamoyl)-benzamide

Base Information

Chemical Name:(R)-N-{1-methyl-2-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-piperidin-1-yl]-ethyl}-4-(2-phenoxy-phenylsulfamoyl)-benzamide
CAS No.:1147098-78-9
Molecular Formula:C₃₃H₄₀N₄O₅S
Molecular Weight:604.77
Hs Code.:

Synonyms:(R)-N-{1-methyl-2-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-piperidin-1-yl]-ethyl}-4-(2-phenoxy-phenylsulfamoyl)-benzamide

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Chemical Property of (R)-N-{1-methyl-2-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-piperidin-1-yl]-ethyl}-4-(2-phenoxy-phenylsulfamoyl)-benzamide

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Technology Process of (R)-N-{1-methyl-2-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-piperidin-1-yl]-ethyl}-4-(2-phenoxy-phenylsulfamoyl)-benzamide

There total 4 articles about (R)-N-{1-methyl-2-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-piperidin-1-yl]-ethyl}-4-(2-phenoxy-phenylsulfamoyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 14759-08-1
4-(2-(pyrrolidin-1-yl)ethyl)piperidine

: 1147098-99-4
(R)-2-[4-(2-phenoxy-phenylsulfamoyl)-benzoylamino]-propionic acid

: 1147098-78-9
(R)-N-{1-methyl-2-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-piperidin-1-yl]-ethyl}-4-(2-phenoxy-phenylsulfamoyl)-benzamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 10130-89-9
p-carboxyphenylsulfonyl chloride

: 1147098-78-9
(R)-N-{1-methyl-2-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-piperidin-1-yl]-ethyl}-4-(2-phenoxy-phenylsulfamoyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 20 °C / Cooling with ice; Inert atmosphere

2: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / pH 8

3: water; lithium hydrochloride monohydrate / tetrahydrofuran; methanol / 2 h / 20 °C

4: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C

With lithium hydrochloride monohydrate; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 2688-84-8
2-phenoxyaniline

: 1147098-78-9
(R)-N-{1-methyl-2-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-piperidin-1-yl]-ethyl}-4-(2-phenoxy-phenylsulfamoyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 20 °C / Cooling with ice; Inert atmosphere

2: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / pH 8

3: water; lithium hydrochloride monohydrate / tetrahydrofuran; methanol / 2 h / 20 °C

4: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C

With lithium hydrochloride monohydrate; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;