(R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido-[2,3-d]pyrimidine-4,7(3H,8H)-dione

Base Information

Chemical Name:(R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido-[2,3-d]pyrimidine-4,7(3H,8H)-dione
CAS No.:1227054-01-4
Molecular Formula:C₂₀H₁₉F₂IN₄O₄
Molecular Weight:544.297
Hs Code.:

Synonyms:(R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido-[2,3-d]pyrimidine-4,7(3H,8H)-dione

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Chemical Property of (R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido-[2,3-d]pyrimidine-4,7(3H,8H)-dione

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Technology Process of (R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido-[2,3-d]pyrimidine-4,7(3H,8H)-dione

There total 8 articles about (R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido-[2,3-d]pyrimidine-4,7(3H,8H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1227054-00-3
(R)-5-chloro-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-8-methylpyrido[2,3-d]pyrimidine-4,7-(3H,8H)-dione

: 29632-74-4
2-fluro-4-iodoaniline

: 1227054-01-4
(R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido-[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -5 - 20 ℃; Large scale;
DOI:10.1021/op300198a

Reference yield:

: 1402613-56-2
C₇H₆FN₃O₂

: 1227054-01-4
(R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido-[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / tetrahydrofuran; water; methanol / 5 h / 20 °C / Large scale

2: trichlorophosphate / acetonitrile / 50 - 74 °C / Large scale

3: sulfuric acid / 20 h / 60 - 80 °C / Large scale

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 63 h / 63 °C / Large scale

5: lithium hexamethyldisilazane / tetrahydrofuran / -5 - 20 °C / Large scale

With sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; methanol; water; isopropyl alcohol; acetonitrile;
DOI:10.1021/op300198a

Reference yield:

: 1227053-97-5
2-amino-5-fluoro-4-hydroxy-1-methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile

: 1227054-01-4
(R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido-[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / acetonitrile / 50 - 74 °C / Large scale

2: sulfuric acid / 20 h / 60 - 80 °C / Large scale

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 63 h / 63 °C / Large scale

4: lithium hexamethyldisilazane / tetrahydrofuran / -5 - 20 °C / Large scale

With sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; isopropyl alcohol; acetonitrile;
DOI:10.1021/op300198a