N-((2R,3R)-3-[Boc-L-Thr(TBS)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl

Base Information

Chemical Name:N-((2R,3R)-3-[Boc-L-Thr(TBS)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl
CAS No.:694527-94-1
Molecular Formula:C₅₃H₉₁N₅O₁₂Si
Molecular Weight:1018.42
Hs Code.:

Synonyms:N-((2R,3R)-3-[Boc-L-Thr(TBS)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl

Suppliers and Price of N-((2R,3R)-3-[Boc-L-Thr(TBS)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-((2R,3R)-3-[Boc-L-Thr(TBS)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-((2R,3R)-3-[Boc-L-Thr(TBS)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl

There total 12 articles about N-((2R,3R)-3-[Boc-L-Thr(TBS)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 656251-64-8
Boc-L-Thr(TBS)-Gly-OH

: 694527-82-7
N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl

: 694527-94-1
N-((2R,3R)-3-[Boc-L-Thr(TBS)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl

Guidance literature:: With dmap; camphor-10-sulfonic acid; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2003.10.055

Reference yield:

: 2592-18-9
Boc-Thr-OH

: 694527-94-1
N-((2R,3R)-3-[Boc-L-Thr(TBS)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / Et₃N / CH₂Cl₂ / 4 h / 0 - 20 °C

2: 87 percent / Et₃N; 1-hydroxybenzotriazole; EDCI*HCl / CH₂Cl₂ / 15 h / 0 - 20 °C

3: 98 percent / H₂ / Pd/C / ethanol / 2.5 h / 20 °C

4: 96 percent / DMAP; CSA; diisopropylcarbodiimide / CH₂Cl₂ / 20 °C

With dmap; camphor-10-sulfonic acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2003.10.055

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 694527-94-1
N-((2R,3R)-3-[Boc-L-Thr(TBS)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / Et₃N / CH₂Cl₂ / 4 h / 0 - 20 °C

2: 87 percent / Et₃N; 1-hydroxybenzotriazole; EDCI*HCl / CH₂Cl₂ / 15 h / 0 - 20 °C

3: 98 percent / H₂ / Pd/C / ethanol / 2.5 h / 20 °C

4: 96 percent / DMAP; CSA; diisopropylcarbodiimide / CH₂Cl₂ / 20 °C

With dmap; camphor-10-sulfonic acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2003.10.055