4-chloro-N-(6-chloro-2-fluoro-3-(3-fluoropropylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Base Information

Chemical Name:4-chloro-N-(6-chloro-2-fluoro-3-(3-fluoropropylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide
CAS No.:1269667-61-9
Molecular Formula:C₁₆H₁₂Cl₂F₂N₄O₃S₂
Molecular Weight:481.331
Hs Code.:

Synonyms:4-chloro-N-(6-chloro-2-fluoro-3-(3-fluoropropylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

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Chemical Property of 4-chloro-N-(6-chloro-2-fluoro-3-(3-fluoropropylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

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Technology Process of 4-chloro-N-(6-chloro-2-fluoro-3-(3-fluoropropylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

There total 11 articles about 4-chloro-N-(6-chloro-2-fluoro-3-(3-fluoropropylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1269421-25-1
N-(3-amino-4-chloro-2-fluorophenyl)-3-fluoropropane-1-sulfonamide

: 1269667-58-4
4-chlorothieno[3,2-d]pyrimidine-7-carbonyl chloride

: 1269667-61-9
4-chloro-N-(6-chloro-2-fluoro-3-(3-fluoropropylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: In tetrahydrofuran; at 55 ℃; for 2h;

Reference yield:

: 16234-10-9
3H-thieno[3,2-d]pyrimidin-4-one

: 1269667-61-9
4-chloro-N-(6-chloro-2-fluoro-3-(3-fluoropropylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / acetic acid / 8 h / 100 °C

1.2: 20 °C

2.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 3 h / 120 °C / 15514.9 Torr / Autoclave

3.1: trichlorophosphate / 2 h / Reflux

3.2: Cooling with ice

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 20 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 0 - 20 °C

6.1: tetrahydrofuran / 2 h / 55 °C

With oxalyl dichloride; lithium hydroxide monohydrate; water; bromine; triethylamine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran; acetic acid;

Reference yield:

: 31169-25-2
7-bromothieno[3,2-d]pyrimidine-4(3H)-one

: 1269667-61-9
4-chloro-N-(6-chloro-2-fluoro-3-(3-fluoropropylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 3 h / 120 °C / 15514.9 Torr / Autoclave

2.1: trichlorophosphate / 2 h / Reflux

2.2: Cooling with ice

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 0 - 20 °C

5.1: tetrahydrofuran / 2 h / 55 °C

With oxalyl dichloride; lithium hydroxide monohydrate; water; triethylamine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran;