N-[4-(butylamino)butanoyl]-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

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Chemical Name:N-[4-(butylamino)butanoyl]-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide
CAS No.:1101984-27-3
Molecular Formula:C₂₇H₃₂ClFN₄O₆S
Molecular Weight:595.092
Hs Code.:

Synonyms:N-[4-(butylamino)butanoyl]-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

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Chemical Property of N-[4-(butylamino)butanoyl]-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

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Technology Process of N-[4-(butylamino)butanoyl]-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

There total 11 articles about N-[4-(butylamino)butanoyl]-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1101244-18-1
C₃₅H₃₈ClFN₄O₈S

: 1101984-27-3
N-[4-(butylamino)butanoyl]-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

Guidance literature:: C₃₅H₃₈ClFN₄O₈S; With trifluoroacetic acid; at 20 ℃;

With hydrogenchloride; In water; pH=3;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1101984-27-3
N-[4-(butylamino)butanoyl]-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium carbonate / dichloromethane; water / 144 h / Reflux

2.1: potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / Inert atmosphere; Reflux

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 750.08 Torr

4.1: magnesium(II) perchlorate / acetonitrile / 15 h / 20 °C

5.1: dmap / propyl cyanide / 72 h / 70 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 0.33 h / 20 °C

7.1: trifluoroacetic acid / 20 °C

7.2: pH 3

With dmap; potassium phosphate; copper(l) iodide; magnesium(II) perchlorate; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium carbonate; trifluoroacetic acid; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In 1,4-dioxane; propyl cyanide; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1093628-67-1
N,N-Dibenzyl-2-fluoro-4-iodoaniline

: 1101984-27-3
N-[4-(butylamino)butanoyl]-5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / Inert atmosphere; Reflux

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 750.08 Torr

3.1: magnesium(II) perchlorate / acetonitrile / 15 h / 20 °C

4.1: dmap / propyl cyanide / 72 h / 70 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 0.33 h / 20 °C

6.1: trifluoroacetic acid / 20 °C

6.2: pH 3

With dmap; potassium phosphate; copper(l) iodide; magnesium(II) perchlorate; hydrogen; sodium hydride; trifluoroacetic acid; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In 1,4-dioxane; propyl cyanide; ethanol; N,N-dimethyl-formamide; acetonitrile;