GSA 10

Base Information

Chemical Name:GSA 10
CAS No.:300833-95-8
Molecular Formula:C₂₆H₃₀N₂O₅
Molecular Weight:450.535
Hs Code.:
Mol file:300833-95-8.mol

Synonyms:propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

Suppliers and Price of GSA 10

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
GSA 10
10mg
$ 466.00

TRC
GSA10
5mg
$ 80.00

Tocris
GSA10 ≥98%(HPLC)
10
$ 203.00

Tocris
GSA10 ≥98%(HPLC)
50
$ 771.00

Cayman Chemical
GSA 10 ≥95%
50mg
$ 578.00

Cayman Chemical
GSA 10 ≥95%
25mg
$ 306.00

Cayman Chemical
GSA 10 ≥95%
5mg
$ 68.00

Cayman Chemical
GSA 10 ≥95%
10mg
$ 129.00

Biosynth Carbosynth
GSA 10
10 mg
$ 125.00

Biosynth Carbosynth
GSA 10
50 mg
$ 438.00

Total 9 raw suppliers

Chemical Property of GSA 10

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

GSA 10 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 μM). Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site.
Uses GSA 10 is a novel small-molecule positive modulator of smoothened. GSA 10 may have therapeutic interests in regenerative medicine.

Technology Process of GSA 10

There total 2 articles about GSA 10 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 94-12-2
risocaine

: 52851-59-9
1-hexyl-3-ethoxycarbonyl-4-hydroxy-2(1H)-quinolinone

: 300833-95-8
propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

Guidance literature:: In toluene; at 250 ℃; Microwave irradiation;
DOI:10.1016/j.ejmech.2016.05.062

Reference yield:

: 4746-32-1
N-hexylaniline

: 300833-95-8
propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: Microwave irradiation; Heating

2: toluene / 250 °C / Microwave irradiation

In toluene;
DOI:10.1016/j.ejmech.2016.05.062