5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole

Base Information

Chemical Name:5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole
CAS No.:1567334-96-6
Molecular Formula:C₂₁H₂₁ClN₂O₂
Molecular Weight:368.863
Hs Code.:

Synonyms:5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole

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Chemical Property of 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole

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Technology Process of 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole

There total 6 articles about 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₁₉ClN₂O₂

: 1567334-96-6
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 1551.49 Torr;
DOI:10.1016/j.bmcl.2018.10.007

Reference yield:

: C₁₆H₁₃ClN₂O₂

: 1567334-96-6
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 60 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; ethanol / 80 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 1551.49 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; 1,2-dichloro-ethane; toluene;
DOI:10.1016/j.bmcl.2018.10.007

Reference yield:

: 2881-63-2
ethyl (4-chlorobenzoyl)acetate

: 1567334-96-6
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1: phosphorus trichloride / 1,2-dichloro-ethane / 60 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 60 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; ethanol / 80 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 1551.49 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; phosphorus trichloride; In methanol; ethanol; 1,2-dichloro-ethane; toluene;
DOI:10.1016/j.bmcl.2018.10.007