N⁴-isopropyl-N²-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-5-nitropyridine-2,4-diamine

Base Information

• Chemical Name: N⁴-isopropyl-N²-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-5-nitropyridine-2,4-diamine
• CAS No.: 1612171-76-2
• Molecular Formula: C₁₈H₂₅N₇O₃
• Molecular Weight: 387.442

Synonyms:N⁴-isopropyl-N²-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-5-nitropyridine-2,4-diamine

Chemical Property of N⁴-isopropyl-N²-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-5-nitropyridine-2,4-diamine

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Technology Process of N⁴-isopropyl-N²-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-5-nitropyridine-2,4-diamine

There total 1 articles about N⁴-isopropyl-N²-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-5-nitropyridine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dibromo-5-nitropyridine (4487-57-4) → N4-isopropyl-N2-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-5-nitropyridine-2,4-diamine (1612171-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane

2: caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; triethylamine; XPhos; In dichloromethane;

Reference yield:

N4-isopropyl-N2-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-5-nitropyridine-2,4-diamine (1612171-76-2) → 1-isopropyl-N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-2-(18-phenyl-2,5,8,11,14,17-hexaoxaoctadecyl)-1H-imidazo[4,5-c]pyridin-6-amine

Guidance literature:

Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / methanol; ethyl acetate

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16 h / 10 - 20 °C

3: acetic acid / 10 h / 120 °C / Microwave irradiation

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; ethyl acetate;

Reference yield:

N4-isopropyl-N2-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-5-nitropyridine-2,4-diamine (1612171-76-2) → 4-((4-(2-((tert-butyldimethylsilyl)oxy)ethyl)piperazin-1-yl)methyl)-N-(4-(isopropylamino)-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)pyridin-3-yl)benzamide

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol; ethyl acetate

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; ethyl acetate;

upstream raw materials:

2,4-dibromo-5-nitropyridine

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