4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid

Base Information

Chemical Name:4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid
CAS No.:467423-51-4
Molecular Formula:C₃₆H₄₇N₅O₆S
Molecular Weight:677.865
Hs Code.:

4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid

Synonyms:4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid

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Chemical Property of 4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid

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Technology Process of 4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid

There total 9 articles about 4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-amino-2,2-dimethylbutanoic acid hydrochloride

: 254737-86-5
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide

: 467423-51-4
4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid

Guidance literature:: 4-amino-2,2-dimethylbutanoic acid hydrochloride; 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide; With 3 A molecular sieve; sodium acetate; acetic acid; In dichloromethane; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 2h; Further stages.;
DOI:10.1021/jm020138n

Reference yield:

: 160313-50-8
2-[(2'-bromo-5'-cyano)phenyl]-1,3-dioxolane

: 467423-51-4
4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: 70.5 g / DIBAL-H / toluene / 17 h / -78 - 20 °C

2.1: sodium borohydride / ethanol / 2 h / 0 °C

3.1: 31.1 g / carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 2 h / 0 °C

4.1: sodium hydride / dimethylformamide / 0.25 h / 0 - 20 °C

4.2: 42.7 g / dimethylformamide / 14 h

5.1: 8.2 g / 1 N HCl / tetrahydrofuran / 1 h / 65 °C

6.1: 77 percent / (Ph₃P)4Pd; aq. sodium carbonate / toluene; aq. ethanol / 2 h / Heating

7.1: 73 percent / 6 N aq. HCl / aq. ethanol / 1 h / Heating

8.1: 3A molecular sieves; sodium acetate; glacial acetic acid / CH₂Cl₂ / 0.17 h / 20 °C

8.2: NaB(AcO)3H / CH₂Cl₂ / 2 h

With hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; 3 A molecular sieve; sodium acetate; sodium hydride; diisobutylaluminium hydride; sodium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 6.1: Suzuki coupling;
DOI:10.1021/jm020138n

Reference yield:

: 160313-48-4
2-[(2'-bromo-5'-hydroxymethyl)phenyl]-1,3-dioxolane

: 467423-51-4
4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 31.1 g / carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 2 h / 0 °C

2.1: sodium hydride / dimethylformamide / 0.25 h / 0 - 20 °C

2.2: 42.7 g / dimethylformamide / 14 h

3.1: 8.2 g / 1 N HCl / tetrahydrofuran / 1 h / 65 °C

4.1: 77 percent / (Ph₃P)4Pd; aq. sodium carbonate / toluene; aq. ethanol / 2 h / Heating

5.1: 73 percent / 6 N aq. HCl / aq. ethanol / 1 h / Heating

6.1: 3A molecular sieves; sodium acetate; glacial acetic acid / CH₂Cl₂ / 0.17 h / 20 °C

6.2: NaB(AcO)3H / CH₂Cl₂ / 2 h

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; 3 A molecular sieve; sodium acetate; sodium hydride; sodium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 4.1: Suzuki coupling;
DOI:10.1021/jm020138n