N-(4-amino-2-methylquinolin-6-yl)-2-[4-((trifluoroacetylamino)methyl)phenoxymethyl]benzamide

Base Information

Chemical Name:N-(4-amino-2-methylquinolin-6-yl)-2-[4-((trifluoroacetylamino)methyl)phenoxymethyl]benzamide
CAS No.:1296210-31-5
Molecular Formula:C₂₇H₂₃F₃N₄O₃
Molecular Weight:508.5
Hs Code.:

Synonyms:N-(4-amino-2-methylquinolin-6-yl)-2-[4-((trifluoroacetylamino)methyl)phenoxymethyl]benzamide

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Chemical Property of N-(4-amino-2-methylquinolin-6-yl)-2-[4-((trifluoroacetylamino)methyl)phenoxymethyl]benzamide

Chemical Property:

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Technology Process of N-(4-amino-2-methylquinolin-6-yl)-2-[4-((trifluoroacetylamino)methyl)phenoxymethyl]benzamide

There total 6 articles about N-(4-amino-2-methylquinolin-6-yl)-2-[4-((trifluoroacetylamino)methyl)phenoxymethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5443-31-2
2-methyl-quinoline-4,6-diamine

: C₁₇H₁₃ClF₃NO₃

: 1296210-31-5
N-(4-amino-2-methylquinolin-6-yl)-2-[4-((trifluoroacetylamino)methyl)phenoxymethyl]benzamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 35 ℃;
DOI:10.1016/j.ejmech.2011.01.040

Reference yield:

: 2417-73-4
methyl 2-bromomethylbenzoate

: 1296210-31-5
N-(4-amino-2-methylquinolin-6-yl)-2-[4-((trifluoroacetylamino)methyl)phenoxymethyl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 30 °C

2.1: sodium hydroxide / tetrahydrofuran; methanol; water / 3 h / 90 °C

2.2: pH 3 - 4 / Cooling with ice

3.1: pyridine; N-ethyl-N,N-diisopropylamine / dichloromethane / 15 - 20 °C

3.2: pH Ca_. 2 / Cooling

4.1: oxalyl dichloride / toluene / 25 °C

5.1: pyridine / dichloromethane / 0 - 35 °C

With pyridine; oxalyl dichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2011.01.040

Reference yield:

: 1296210-30-4
2-[4-((trifluoroacetylamino)methyl)phenoxy]methylbenzoic acid

: 1296210-31-5
N-(4-amino-2-methylquinolin-6-yl)-2-[4-((trifluoroacetylamino)methyl)phenoxymethyl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / toluene / 25 °C

2: pyridine / dichloromethane / 0 - 35 °C

With pyridine; oxalyl dichloride; In dichloromethane; toluene;
DOI:10.1016/j.ejmech.2011.01.040