N^α-benzoyl-N^ε-(2'-trimethylsilyl)ethanesulfonyl-N^ε-4''-methoxybenzyl-L-α-vinyllysinol

Base Information

• Chemical Name: N^α-benzoyl-N^ε-(2'-trimethylsilyl)ethanesulfonyl-N^ε-4''-methoxybenzyl-L-α-vinyllysinol
• CAS No.: 925451-46-3
• Molecular Formula: C₂₈H₄₂N₂O₅SSi
• Molecular Weight: 546.803

Synonyms:N^α-benzoyl-N^ε-(2'-trimethylsilyl)ethanesulfonyl-N^ε-4''-methoxybenzyl-L-α-vinyllysinol

Chemical Property of N^α-benzoyl-N^ε-(2'-trimethylsilyl)ethanesulfonyl-N^ε-4''-methoxybenzyl-L-α-vinyllysinol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-benzoyl-N^ε-(2'-trimethylsilyl)ethanesulfonyl-N^ε-4''-methoxybenzyl-L-α-vinyllysinol

There total 8 articles about N^α-benzoyl-N^ε-(2'-trimethylsilyl)ethanesulfonyl-N^ε-4''-methoxybenzyl-L-α-vinyllysinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl Nα-benzoyl-Nε-(2''-trimethylsilyl)ethanesulfonyl-Nε-4'''-methoxybenzyl-L-α-vinyllysinate (925451-40-7) → Nα-benzoyl-Nε-(2'-trimethylsilyl)ethanesulfonyl-Nε-4''-methoxybenzyl-L-α-vinyllysinol (925451-46-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1021/ja067240k

Reference yield:

N-(2'-trimethylsilyl)ethanesulfonyl-4-methoxybenzylamine (925451-33-8) → Nα-benzoyl-Nε-(2'-trimethylsilyl)ethanesulfonyl-Nε-4''-methoxybenzyl-L-α-vinyllysinol (925451-46-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: 77 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 91 percent / sodium iodide / acetone / 14 h / 50 °C / Heating

3.1: LDA; n-BuLi / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / -78 °C

3.2: tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 5 h / -78 °C

4.1: 96 percent / LiAlH₄ / tetrahydrofuran / 3 h / 0 °C

With lithium aluminium tetrahydride; n-butyllithium; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; acetone;

DOI:10.1021/ja067240k

Reference yield:

N-(2'-trimethylsilyl)ethanesulfonyl-N-(4''-chlorobutyl)-4-methoxybenzylamine (925451-36-1) → Nα-benzoyl-Nε-(2'-trimethylsilyl)ethanesulfonyl-Nε-4''-methoxybenzyl-L-α-vinyllysinol (925451-46-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 91 percent / sodium iodide / acetone / 14 h / 50 °C / Heating

2.1: LDA; n-BuLi / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / -78 °C

2.2: tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 5 h / -78 °C

3.1: 96 percent / LiAlH₄ / tetrahydrofuran / 3 h / 0 °C

With lithium aluminium tetrahydride; n-butyllithium; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; acetone;

DOI:10.1021/ja067240k

upstream raw materials:

(1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl N^α-benzoyl-N^ε-(2''-trimethylsilyl)ethanesulfonyl-N^ε-4'''-methoxybenzyl-L-α-vinyllysinate

N-(2'-trimethylsilyl)ethanesulfonyl-4-methoxybenzylamine

N-(2'-trimethylsilyl)ethanesulfonyl-N-(4''-chlorobutyl)-4-methoxybenzylamine

N-(2'-trimethylsilyl)ethanesulfonyl-N-4''-iodobutyl-4-methoxybenzylamine

Downstream raw materials:

methyl N^α-benzoyl-N^ε-(2''-trimethylsilyl)ethanesulfonyl-N^ε-4'''-methoxybenzyl-L-α-(2'E-benzenesulfonyl-2'-fluoro)vinyllysinate

methyl N^α-benzoyl-N^ε-(2''-trimethylsilyl)ethanesulfonyl-N^ε-4'''-methoxybenzyl-L-α-(2'Z-fluoro)vinyllysinate

methyl N^α-benzoyl-N^ε-(2'-trimethylsilyl)ethanesulfonyl-N^ε-4''-methoxybenzyl-L-α-vinyllysinate

methyl N^α-benzoyl-N^ε-(2'-trimethylsilyl)ethanesulfonyl-N^ε-4''-methoxybenzyl-L-α-formyllysinate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 925451-46-3 N^α-benzoyl-N^ε-(2'-trimethylsilyl)ethanesulfonyl-N^ε-4''-methoxybenzyl-L-α-vinyllysinol

Send

Send

Metric Ton KG G Pound L ML

Send

Send