(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((3-methylbenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol

Base Information

Chemical Name:(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((3-methylbenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
CAS No.:35940-03-5
Molecular Formula:C₁₈H₂₁N₅O₄
Molecular Weight:371.396
Hs Code.:

Synonyms:(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((3-methylbenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol

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Chemical Property of (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((3-methylbenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol

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Technology Process of (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((3-methylbenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol

There total 5 articles about (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((3-methylbenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2004-06-0
6-Chloropurine riboside

: 100-81-2
3-methyl-benzenemethanamine

: 35940-03-5
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((3-methylbenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol

Guidance literature:: With triethylamine; In neat (no solvent); at 210 ℃; for 0.0166667h; under 12929 Torr; Irradiation;
DOI:10.1016/j.bioorg.2019.103449

Reference yield:

: 42365-50-4
3-methyl-benzylamine; hydrochloride

: 2004-06-0
6-Chloropurine riboside

: 35940-03-5
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((3-methylbenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol

Guidance literature:: With triethylamine; In propan-1-ol; at 70 ℃; for 8h;

Reference yield:

: 620-23-5
m-tolyl aldehyde

: 35940-03-5
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((3-methylbenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 6 h / 20 °C

2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 760.05 Torr

3: triethylamine / propan-1-ol / 8 h / 70 °C

With hydrogenchloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; triethylamine; palladium 10% on activated carbon; In propan-1-ol; ethanol; water;