(S)-3-tert-Butoxycarbonylamino-N-[3-((S)-1-{[2-(3,4-dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenyl]-succinamic acid benzyl ester

Base Information

• Chemical Name: (S)-3-tert-Butoxycarbonylamino-N-[3-((S)-1-{[2-(3,4-dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenyl]-succinamic acid benzyl ester
• CAS No.: 182196-97-0
• Molecular Formula: C₃₇H₄₄Cl₂N₄O₆
• Molecular Weight: 711.686
• Mol file: 182196-97-0.mol

Synonyms:(S)-3-tert-Butoxycarbonylamino-N-[3-((S)-1-{[2-(3,4-dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenyl]-succinamic acid benzyl ester

Chemical Property of (S)-3-tert-Butoxycarbonylamino-N-[3-((S)-1-{[2-(3,4-dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenyl]-succinamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-tert-Butoxycarbonylamino-N-[3-((S)-1-{[2-(3,4-dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenyl]-succinamic acid benzyl ester

There total 1 articles about (S)-3-tert-Butoxycarbonylamino-N-[3-((S)-1-{[2-(3,4-dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenyl]-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) + N-[(1S)-1-(3-aminophenyl)-2-(pyrrolidin-1-yl)ethyl]-2-(3,4-dichlorophenyl)-N-methylacetamide (155551-42-1) → (S)-3-tert-Butoxycarbonylamino-N-[3-((S)-1-{[2-(3,4-dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenyl]-succinamic acid benzyl ester (182196-97-0)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, 25 deg C, 23 h;

DOI:10.1021/jm960459x

Reference yield:

(S)-3-tert-Butoxycarbonylamino-N-[3-((S)-1-{[2-(3,4-dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenyl]-succinamic acid benzyl ester (182196-97-0) → (S)-3-Amino-N-[3-((S)-1-{[2-(3,4-dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenyl]-succinamic acid; hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: 2N aq. HCl, gl. AcOH, anisole / 0.33 h / 25 °C

2: H₂ / 10percent Pd/C / methanol / 1.33 h / 25 °C

With hydrogenchloride; hydrogen; acetic acid; methoxybenzene; palladium on activated charcoal; In methanol;

DOI:10.1021/jm960459x

Reference yield:

(S)-3-tert-Butoxycarbonylamino-N-[3-((S)-1-{[2-(3,4-dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenyl]-succinamic acid benzyl ester (182196-97-0) → (S)-3-Amino-N-[3-((S)-1-{[2-(3,4-dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenyl]-succinamic acid benzyl ester; hydrochloride

Guidance literature:

With hydrogenchloride; acetic acid; methoxybenzene; at 25 ℃; for 0.333333h;

DOI:10.1021/jm960459x

upstream raw materials:

BOC-L-aspartic acid 4-benzyl ester

N-[(1S)-1-(3-aminophenyl)-2-(pyrrolidin-1-yl)ethyl]-2-(3,4-dichlorophenyl)-N-methylacetamide