(S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(4-((6-(2-(dimethylamino)ethyl)-6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)phenoxy)butan-2-ol

Base Information

• Chemical Name: (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(4-((6-(2-(dimethylamino)ethyl)-6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)phenoxy)butan-2-ol
• CAS No.: 1427039-98-2
• Molecular Formula: C₅₁H₄₈N₄O₅
• Molecular Weight: 796.966
• Mol file: 1427039-98-2.mol

Synonyms:(S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(4-((6-(2-(dimethylamino)ethyl)-6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)phenoxy)butan-2-ol

Chemical Property of (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(4-((6-(2-(dimethylamino)ethyl)-6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)phenoxy)butan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(4-((6-(2-(dimethylamino)ethyl)-6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)phenoxy)butan-2-ol

There total 6 articles about (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(4-((6-(2-(dimethylamino)ethyl)-6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)phenoxy)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(S)-4-(4-((6-(2-(dimethylamino)ethyl)-6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)phenoxy)butane-1,2-diol (1427039-97-1) + 4,4'-dimethoxytrityl chloride (40615-36-9) → (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(4-((6-(2-(dimethylamino)ethyl)-6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)phenoxy)butan-2-ol (1427039-98-2)

Guidance literature:

With pyridine; at 20 ℃; Inert atmosphere;

DOI:10.1080/15257770.2013.765013

Reference yield:

(S)-4-(2-(4-iodophenoxy)ethyl)-2,2-dimethyl-1,3-dioxolane (1088780-69-1) → (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(4-((6-(2-(dimethylamino)ethyl)-6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)phenoxy)butan-2-ol (1427039-98-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: acetic acid / water

2.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 24 h / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

4.1: triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

4.2: 0.42 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: pyridine / 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; acetic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2.1: |Sonogashira Cross-Coupling / 4.1: |Sonogashira Cross-Coupling / 4.2: |Sonogashira Cross-Coupling;

DOI:10.1080/15257770.2013.765013

Reference yield:

(S)-4-(4-((trimethylsilyl)ethynyl)phenoxy)butane-1,2-diol (1427039-95-9) → (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(4-((6-(2-(dimethylamino)ethyl)-6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)phenoxy)butan-2-ol (1427039-98-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

2.1: triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 0.42 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: pyridine / 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 2.1: |Sonogashira Cross-Coupling / 2.2: |Sonogashira Cross-Coupling;

DOI:10.1080/15257770.2013.765013

upstream raw materials:

(S)-4-(4-((trimethylsilyl)ethynyl)phenoxy)butane-1,2-diol

(S)-4-(4-ethynylphenoxy)butane-1,2-diol

(S)-4-(4-((6-(2-(dimethylamino)ethyl)-6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)phenoxy)butane-1,2-diol

4,4'-dimethoxytrityl chloride

Downstream raw materials:

C₆₀H₆₅N₆O₆P