Podophyllinic acid hydrazide

Base Information

• Chemical Name: Podophyllinic acid hydrazide
• CAS No.: 78178-41-3
• Molecular Formula: C₂₂H₂₆N₂O₈
• Molecular Weight: 446.457
• UNII: Q074QWB367
• Nikkaji Number: J1.768.866I
• Wikidata: Q27286842
• Mol file: 78178-41-3.mol

Synonyms:Podophyllinic acid hydrazide;UNII-Q074QWB367;Q074QWB367;78178-41-3;Naphtho(2,3-d)-1,3-dioxole-6-carboxylic acid, 5,6,7,8-tetrahydro-8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-, hydrazide, (5R,6R,7R,8R)-;SCHEMBL9131949;Q27286842

Chemical Property of Podophyllinic acid hydrazide

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 6
• Exact Mass: 446.16891579
• Heavy Atom Count: 32
• Complexity: 639

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)OC)C2C(C(C(C3=CC4=C(C=C23)OCO4)O)CO)C(=O)NN
• Isomeric SMILES: COC1=CC(=CC(=C1OC)OC)[C@H]2[C@H]([C@@H]([C@H](C3=CC4=C(C=C23)OCO4)O)CO)C(=O)NN

Technology Process of Podophyllinic acid hydrazide

There total 2 articles about Podophyllinic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

podofilox (518-28-5) → podophyllinic acid hydrazide (78178-41-3)

Guidance literature:

With acetic acid; hydrazine; In methanol; for 6h; Reflux;

DOI:10.1016/j.bioorg.2019.103384

Reference yield:

→ podophyllinic acid hydrazide (78178-41-3)

Guidance literature:

Podophyllotoxin, Hydrazin, Methanol, Essigsaeure, Siedetemp.;

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + podophyllinic acid hydrazide (78178-41-3) → podofilox (518-28-5)

Guidance literature:

DOI:10.1002/hlca.19590420334

upstream raw materials:

podofilox

Downstream raw materials:

podophyllinic acid furfurylidenehydrazide

podophyllinic acid-([2]thienylmethylene-hydrazide)

(5R)-8c-hydroxy-7t-hydroxymethyl-5r-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6c-carboxylic acid-(N'-lauroyl-hydrazide)

(5R)-8c-hydroxy-7t-hydroxymethyl-5r-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6c-carboxylic acid dodecylidenehydrazide