(E)-5-(tert-butyldiphenylsilyloxy)-N-phenyl-2-(phenylthiomethylene)pentanethioamide

Base Information

• Chemical Name: (E)-5-(tert-butyldiphenylsilyloxy)-N-phenyl-2-(phenylthiomethylene)pentanethioamide
• CAS No.: 1231177-54-0
• Molecular Formula: C₃₄H₃₇NOS₂Si
• Molecular Weight: 567.891
• Mol file: 1231177-54-0.mol

Synonyms:(E)-5-(tert-butyldiphenylsilyloxy)-N-phenyl-2-(phenylthiomethylene)pentanethioamide

Chemical Property of (E)-5-(tert-butyldiphenylsilyloxy)-N-phenyl-2-(phenylthiomethylene)pentanethioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-5-(tert-butyldiphenylsilyloxy)-N-phenyl-2-(phenylthiomethylene)pentanethioamide

There total 6 articles about (E)-5-(tert-butyldiphenylsilyloxy)-N-phenyl-2-(phenylthiomethylene)pentanethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Lawessons reagent (19172-47-5,94367-93-8) + (E)-5-(tert-butyldiphenylsilyloxy)-N-phenyl-2-(phenylthiomethylene)pentanamide (1231177-53-9) → (E)-5-(tert-butyldiphenylsilyloxy)-N-phenyl-2-(phenylthiomethylene)pentanethioamide (1231177-54-0)

Guidance literature:

In tetrahydrofuran; Reflux;

Reference yield:

thiophenol (108-98-5) → (E)-5-(tert-butyldiphenylsilyloxy)-N-phenyl-2-(phenylthiomethylene)pentanethioamide (1231177-54-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

1.2: 0.5 h

2.1: diethylaluminium chloride / dichloromethane; hexane / 0.08 h / 20 °C

2.2: 2 h / 20 °C

2.3: 0.5 h / 20 °C

3.1: 1H-imidazole / dichloromethane / 2 h / 20 °C

4.1: tetrahydrofuran / Reflux

With 1H-imidazole; diethylaluminium chloride; sodium hydride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

(E)-(2-oxo-2H-pyran-3(4H, 5H, 6H)-ylidene)methyl methanesulfonate (151647-02-8) → (E)-5-(tert-butyldiphenylsilyloxy)-N-phenyl-2-(phenylthiomethylene)pentanethioamide (1231177-54-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

1.2: 0.5 h

2.1: diethylaluminium chloride / dichloromethane; hexane / 0.08 h / 20 °C

2.2: 2 h / 20 °C

2.3: 0.5 h / 20 °C

3.1: 1H-imidazole / dichloromethane / 2 h / 20 °C

4.1: tetrahydrofuran / Reflux

With 1H-imidazole; diethylaluminium chloride; sodium hydride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

thiophenol

tert-butylchlorodiphenylsilane

Lawessons reagent

(E)-5-(tert-butyldiphenylsilyloxy)-N-phenyl-2-(phenylthiomethylene)pentanamide

Downstream raw materials:

(E)-5-hydroxy-N-phenyl-2-(phenylthiomethylene)pentanethioamide