2-methyl-2-(4-(8-(4-methylpiperazin-1-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)propanenitrile

Base Information

Chemical Name:2-methyl-2-(4-(8-(4-methylpiperazin-1-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)propanenitrile
CAS No.:1201645-60-4
Molecular Formula:C₂₅H₂₆N₆
Molecular Weight:410.522
Hs Code.:

Synonyms:2-methyl-2-(4-(8-(4-methylpiperazin-1-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)propanenitrile

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Chemical Property of 2-methyl-2-(4-(8-(4-methylpiperazin-1-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)propanenitrile

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Technology Process of 2-methyl-2-(4-(8-(4-methylpiperazin-1-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)propanenitrile

There total 16 articles about 2-methyl-2-(4-(8-(4-methylpiperazin-1-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1201645-64-8
2-(4-(3-acetyl-8-(4-methylpiperazin-1-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

: 1201645-60-4
2-methyl-2-(4-(8-(4-methylpiperazin-1-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)propanenitrile

Guidance literature:: With methanol; potassium carbonate;

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1201645-60-4
2-methyl-2-(4-(8-(4-methylpiperazin-1-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)propanenitrile

Guidance literature:: Multi-step reaction with 13 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

2.2: 25 °C

3.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

4.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

5.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

6.1: hydrogenchloride / acetone / 24 h

7.1: hydrogenchloride / water / 24 h

8.1: potassium acetate / ethanol / 5 h / Reflux

9.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 15 h / 14 °C

10.1: hydrogen / nickel / tetrahydrofuran / 25 °C / 760.05 Torr

11.1: potassium acetate / toluene

12.1: isopentyl nitrite / toluene / 18 h / 80 °C

13.1: methanol; potassium carbonate

With hydrogenchloride; methanol; aluminum (III) chloride; sodium tetrahydroborate; hydrogen; potassium acetate; sodium hydride; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; ozone; trifluoroacetic acid; isopentyl nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 4-(1-cyano-1-methylethyl)benzoic acid chloride

: 1201645-60-4
2-methyl-2-(4-(8-(4-methylpiperazin-1-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)propanenitrile

Guidance literature:: Multi-step reaction with 12 steps

1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

1.2: 25 °C

2.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

3.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

4.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

5.1: hydrogenchloride / acetone / 24 h

6.1: hydrogenchloride / water / 24 h

7.1: potassium acetate / ethanol / 5 h / Reflux

8.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 15 h / 14 °C

9.1: hydrogen / nickel / tetrahydrofuran / 25 °C / 760.05 Torr

10.1: potassium acetate / toluene

11.1: isopentyl nitrite / toluene / 18 h / 80 °C

12.1: methanol; potassium carbonate

With hydrogenchloride; methanol; aluminum (III) chloride; sodium tetrahydroborate; hydrogen; potassium acetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; ozone; trifluoroacetic acid; isopentyl nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;