(2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Name:(2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester
CAS No.:857478-37-6
Molecular Formula:C₅₈H₇₈N₄O₉Si
Molecular Weight:1003.36
Hs Code.:

(2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester

Synonyms:(2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Property of (2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester

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Technology Process of (2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester

There total 20 articles about (2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (2R,4S)-1-[(S)-2-((S)-2-Amino-2-methyl-butyrylamino)-3-phenyl-propionyl]-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester

: 857478-19-4
(2S,9R)-9-(tert-butyldiphenylsiloxy)-8-oxo-2-(tert-butoxycarbonyl)amino-decanoic acid

: 857478-37-6
(2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol050991r

Reference yield:

: 561038-05-9
(R)-2-(tert-butyldiphenylsilanyloxy)propionic acid methyl ester

: 857478-37-6
(2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: LiOH / tetrahydrofuran; H₂O

2.1: 2.91 g / EDC; DIPEA / CH₂Cl₂

3.1: Mg

3.2: 89 percent / tetrahydrofuran / 3 h / 20 °C

4.1: 55 percent / second-generation Grubbs RCM catalyst / 1,2-dichloro-ethane / 168 h / 20 °C

5.1: 94 percent / H₂ / Pd/C / methanol / 6 h / 760 Torr

6.1: 78 percent / HOBt; EDCI; i-Pr₂NEt / CH₂Cl₂ / 24 h / 20 °C

With lithium hydroxide; hydrogen; benzotriazol-1-ol; magnesium; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; 3.2: Grignard reaction;
DOI:10.1021/ol050991r

Reference yield:

: 857478-12-7
(2R)-N-methoxy-N-methyl-2-(t-butyldiphenylsilyloxy)propanamide

: 857478-37-6
(2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Mg

1.2: 89 percent / tetrahydrofuran / 3 h / 20 °C

2.1: 55 percent / second-generation Grubbs RCM catalyst / 1,2-dichloro-ethane / 168 h / 20 °C

3.1: 94 percent / H₂ / Pd/C / methanol / 6 h / 760 Torr

4.1: 78 percent / HOBt; EDCI; i-Pr₂NEt / CH₂Cl₂ / 24 h / 20 °C

With hydrogen; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In methanol; dichloromethane; 1,2-dichloro-ethane; 1.2: Grignard reaction;
DOI:10.1021/ol050991r