N-(tert-butyloxycarbonyl)-S-{[({4-[4'-(tert-butyloxycarbonyl)amino]benzyl}phenyl)amino]carbonyl}glutathione

Base Information

• Chemical Name: N-(tert-butyloxycarbonyl)-S-{[({4-[4'-(tert-butyloxycarbonyl)amino]benzyl}phenyl)amino]carbonyl}glutathione
• CAS No.: 474124-94-2
• Molecular Formula: C₃₄H₄₅N₅O₁₁S
• Molecular Weight: 731.824
• Mol file: 474124-94-2.mol

Synonyms:N-(tert-butyloxycarbonyl)-S-{[({4-[4'-(tert-butyloxycarbonyl)amino]benzyl}phenyl)amino]carbonyl}glutathione

Chemical Property of N-(tert-butyloxycarbonyl)-S-{[({4-[4'-(tert-butyloxycarbonyl)amino]benzyl}phenyl)amino]carbonyl}glutathione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butyloxycarbonyl)-S-{[({4-[4'-(tert-butyloxycarbonyl)amino]benzyl}phenyl)amino]carbonyl}glutathione

There total 5 articles about N-(tert-butyloxycarbonyl)-S-{[({4-[4'-(tert-butyloxycarbonyl)amino]benzyl}phenyl)amino]carbonyl}glutathione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

N-tert-butyloxycarbonylglutathione (137342-09-7) + 4-{4'-[(tert-butyloxycarbonyl)amino]benzyl}phenylisocyanate (474124-93-1) → N-(tert-butyloxycarbonyl)-S-{[({4-[4'-(tert-butyloxycarbonyl)amino]benzyl}phenyl)amino]carbonyl}glutathione (474124-94-2)

Guidance literature:

In acetone; at 20 ℃; for 12.5h;

DOI:10.1021/tx0255020

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-(tert-butyloxycarbonyl)-S-{[({4-[4'-(tert-butyloxycarbonyl)amino]benzyl}phenyl)amino]carbonyl}glutathione (474124-94-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / NaOH / H₂O; dioxane / 17 h / 20 °C

2: triethylamine / acetone / 2 h / 0 °C

3: sodium azide / acetone; H₂O / 1 h / 0 °C

4: toluene / 1 h / 100 °C

5: 69 percent / acetone / 12.5 h / 20 °C

With sodium hydroxide; sodium azide; triethylamine; In 1,4-dioxane; water; acetone; toluene;

DOI:10.1021/tx0255020

Reference yield:

4-(4'-aminobenzyl)benzoic acid (10099-39-5) → N-(tert-butyloxycarbonyl)-S-{[({4-[4'-(tert-butyloxycarbonyl)amino]benzyl}phenyl)amino]carbonyl}glutathione (474124-94-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / NaOH / H₂O; dioxane / 17 h / 20 °C

2: triethylamine / acetone / 2 h / 0 °C

3: sodium azide / acetone; H₂O / 1 h / 0 °C

4: toluene / 1 h / 100 °C

5: 69 percent / acetone / 12.5 h / 20 °C

With sodium hydroxide; sodium azide; triethylamine; In 1,4-dioxane; water; acetone; toluene;

DOI:10.1021/tx0255020

upstream raw materials:

N-tert-butyloxycarbonylglutathione

4-{4'-[(tert-butyloxycarbonyl)amino]benzyl}phenylisocyanate

di-tert-butyl dicarbonate

4-(4'-aminobenzyl)benzoic acid