tert-butyl (3-(benzyloxy)-2-(ethylcarbamoyl)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxopyridin-1(4H)-yl)(methyl)carbamate

Base Information

Chemical Name:tert-butyl (3-(benzyloxy)-2-(ethylcarbamoyl)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxopyridin-1(4H)-yl)(methyl)carbamate
CAS No.:1616278-00-2
Molecular Formula:C₃₀H₃₂FN₅O₅S
Molecular Weight:593.679
Hs Code.:

Synonyms:tert-butyl (3-(benzyloxy)-2-(ethylcarbamoyl)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxopyridin-1(4H)-yl)(methyl)carbamate

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Chemical Property of tert-butyl (3-(benzyloxy)-2-(ethylcarbamoyl)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxopyridin-1(4H)-yl)(methyl)carbamate

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Technology Process of tert-butyl (3-(benzyloxy)-2-(ethylcarbamoyl)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxopyridin-1(4H)-yl)(methyl)carbamate

There total 16 articles about tert-butyl (3-(benzyloxy)-2-(ethylcarbamoyl)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxopyridin-1(4H)-yl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616277-99-6
3-(benzyloxy)-1-((tert-butoxycarbonyl)(methyl)amino)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid

: 75-04-7,85404-22-4
ethylamine

: 1616278-00-2
tert-butyl (3-(benzyloxy)-2-(ethylcarbamoyl)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxopyridin-1(4H)-yl)(methyl)carbamate

Guidance literature:: With chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1.5h;

Reference yield:

: 1616277-91-8
C₁₃H₁₇FN₂O₂S

: 1616278-00-2
tert-butyl (3-(benzyloxy)-2-(ethylcarbamoyl)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxopyridin-1(4H)-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / methanol / 1 h / 20 °C

2.1: chloroform / 20 °C

3.1: hydrogenchloride / chloroform; tert-butyl methyl ether / 2 h / 20 °C

4.1: ethanol / 4 h / 80 °C

4.2: 16 h / 80 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 25 °C

6.1: chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h

With hydrogenchloride; water; chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; tert-butyl methyl ether; chloroform;

Reference yield:

: 1332855-99-8
C₈H₉FN₂S

: 1616278-00-2
tert-butyl (3-(benzyloxy)-2-(ethylcarbamoyl)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxopyridin-1(4H)-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloroform / 20 °C

2.1: hydrogenchloride / chloroform; tert-butyl methyl ether / 2 h / 20 °C

3.1: ethanol / 4 h / 80 °C

3.2: 16 h / 80 °C

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 25 °C

5.1: chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h

With hydrogenchloride; water; chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; tert-butyl methyl ether; chloroform;