N₁,N₆-di(2R-t-butyldimethylsilyloxy-1S-indanyl)-2R,5R-dibenzyloxy-3R-hydroxyhexanediamide

Base Information

• Chemical Name: N₁,N₆-di(2R-t-butyldimethylsilyloxy-1S-indanyl)-2R,5R-dibenzyloxy-3R-hydroxyhexanediamide
• CAS No.: 214139-81-8
• Molecular Formula: C₅₀H₆₈N₂O₇Si₂
• Molecular Weight: 865.27

Synonyms:N₁,N₆-di(2R-t-butyldimethylsilyloxy-1S-indanyl)-2R,5R-dibenzyloxy-3R-hydroxyhexanediamide

Chemical Property of N₁,N₆-di(2R-t-butyldimethylsilyloxy-1S-indanyl)-2R,5R-dibenzyloxy-3R-hydroxyhexanediamide

Chemical Property:

Purity/Quality:

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Technology Process of N₁,N₆-di(2R-t-butyldimethylsilyloxy-1S-indanyl)-2R,5R-dibenzyloxy-3R-hydroxyhexanediamide

There total 4 articles about N₁,N₆-di(2R-t-butyldimethylsilyloxy-1S-indanyl)-2R,5R-dibenzyloxy-3R-hydroxyhexanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

N1,N6-di(2R-t-butyldimethylsilyloxy-1S-indanyl)-2R,5R-dibenzyloxy-3R,4R-dihydroxy-3,4-O-thiocarbonylhexanediamide (214139-80-7) → N1,N6-di(2R-t-butyldimethylsilyloxy-1S-indanyl)-2R,5R-dibenzyloxy-3R-hydroxyhexanediamide (214139-81-8)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 20h; Heating;

DOI:10.1016/S0040-4020(00)00220-9

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → N1,N6-di(2R-t-butyldimethylsilyloxy-1S-indanyl)-2R,5R-dibenzyloxy-3R-hydroxyhexanediamide (214139-81-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / lutidine / CH₂Cl₂ / 4 h / 0 °C

2: 92 percent / 1,2-dichloro-ethane / 22 h / Heating

3: 20 percent / Bu₃SnH; AIBN / toluene / 20 h / Heating

With 2,2'-azobis(isobutyronitrile); lutidine; tri-n-butyl-tin hydride; In dichloromethane; 1,2-dichloro-ethane; toluene; 1: silylation / 2: Substitution / 3: Reduction;

DOI:10.1016/S0040-4020(00)00220-9

Reference yield:

BEA369 (213895-65-9) → N1,N6-di(2R-t-butyldimethylsilyloxy-1S-indanyl)-2R,5R-dibenzyloxy-3R-hydroxyhexanediamide (214139-81-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / lutidine / CH₂Cl₂ / 4 h / 0 °C

2: 92 percent / 1,2-dichloro-ethane / 22 h / Heating

3: 20 percent / Bu₃SnH; AIBN / toluene / 20 h / Heating

With 2,2'-azobis(isobutyronitrile); lutidine; tri-n-butyl-tin hydride; In dichloromethane; 1,2-dichloro-ethane; toluene; 1: silylation / 2: Substitution / 3: Reduction;

DOI:10.1016/S0040-4020(00)00220-9

upstream raw materials:

N₁,N₆-di(2R-t-butyldimethylsilyloxy-1S-indanyl)-2R,5R-dibenzyloxy-3R,4R-dihydroxy-3,4-O-thiocarbonylhexanediamide

t-butyldimethylsiyl triflate

BEA369

N₁,N₆-di(2R-t-butyldimethylsilyloxy-1S-indanyl)-2R,5R-dibenzyloxy-3R,4R-dihydroxyhexanediamide

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