Methyl 2-fluoro-3-(4-methylphenyl)-3-oxopropanoate

Base Information

Chemical Name:Methyl 2-fluoro-3-(4-methylphenyl)-3-oxopropanoate
CAS No.:76435-48-8
Molecular Formula:C11H11 F O3
Molecular Weight:210.2016432
Hs Code.:2918300090
DSSTox Substance ID:DTXSID90505554
Mol file:76435-48-8.mol

Synonyms:76435-48-8;methyl 2-fluoro-3-(4-methylphenyl)-3-oxopropanoate;DTXSID90505554

Suppliers and Price of Methyl 2-fluoro-3-(4-methylphenyl)-3-oxopropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Methyl 2-fluoro-3-(4-methylphenyl)-3-oxopropanoate

Chemical Property:

PSA：43.37000
LogP:1.68880
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:210.06922237
Heavy Atom Count:15
Complexity:244

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(=O)C(C(=O)OC)F

Technology Process of Methyl 2-fluoro-3-(4-methylphenyl)-3-oxopropanoate

There total 2 articles about Methyl 2-fluoro-3-(4-methylphenyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 22027-51-6
3-oxo-3-p-tolyl-propionic acid methyl ester

: 76435-48-8
methyl 2-fluoro-3-oxo-3-(p-tolyl)propanoate

Guidance literature:: With Selectfluor; In acetonitrile; Reflux;
DOI:10.1002/adsc.201800831

Reference yield:

: 122-00-9
para-methylacetophenone

: 76435-48-8
methyl 2-fluoro-3-oxo-3-(p-tolyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 3 h / Reflux

2: Selectfluor / acetonitrile / 50 °C

With sodium hydride; Selectfluor; In tetrahydrofuran; acetonitrile;
DOI:10.1021/acs.orglett.8b02503