1-Propanone, 2,3,3,3-tetrafluoro-1-(4-methylphenyl)- (9CI)

Base Information

• Chemical Name: 1-Propanone, 2,3,3,3-tetrafluoro-1-(4-methylphenyl)- (9CI)
• CAS No.: 76435-42-2
• Molecular Formula: C10H8 F4 O
• Molecular Weight: 220.167
• Hs Code.: 2914700090
• Mol file: 76435-42-2.mol

Synonyms:2,3,3,3-Tetrafluoro-4'-methylpropiophenone

Chemical Property of 1-Propanone, 2,3,3,3-tetrafluoro-1-(4-methylphenyl)- (9CI)

Chemical Property:

• PSA: 17.07000
• LogP: 3.07810

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Propanone, 2,3,3,3-tetrafluoro-1-(4-methylphenyl)- (9CI)

There total 4 articles about 1-Propanone, 2,3,3,3-tetrafluoro-1-(4-methylphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C17H12F8N2O2S → 2,3,3,3-Tetrafluoro-1-p-tolyl-propan-1-one (76435-42-2)

Guidance literature:

With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; water; N-ethyl-N,N-diisopropylamine; In chloroform; at 25 ℃; for 18h; chemoselective reaction; Sealed tube; Glovebox; Inert atmosphere;

DOI:10.1002/anie.202116190

Reference yield:

2,2,3,3,3-pentafluoro-1-(p-tolyl)propan-1-one (10116-95-7) → 2,3,3,3-Tetrafluoro-1-p-tolyl-propan-1-one (76435-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl acetate / 12 h / 40 °C / Acidic conditions

2: bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; N-ethyl-N,N-diisopropylamine; water / chloroform / 18 h / 25 °C / Sealed tube; Glovebox; Inert atmosphere

With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; water; N-ethyl-N,N-diisopropylamine; In chloroform; ethyl acetate;

DOI:10.1002/anie.202116190

Reference yield:

1-((E)-1-Ethoxy-2,3,3,3-tetrafluoro-propenyl)-4-methyl-benzene → 2,3,3,3-Tetrafluoro-1-p-tolyl-propan-1-one (76435-42-2)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 18h; Yield given;

DOI:10.1016/S0022-1139(00)81242-7

upstream raw materials:

1-(p-Tolyl)-perfluorpropen

2,2,3,3,3-pentafluoro-1-(p-tolyl)propan-1-one

Downstream raw materials:

ethyl 2-fluoro-3-(4-methylphenyl)-3-oxopropanoate