4-methyl-N-(4-chloro-2-phenylethynyl-phenyl)-benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-(4-chloro-2-phenylethynyl-phenyl)-benzenesulfonamide
• CAS No.: 946162-01-2
• Molecular Formula: C₂₁H₁₆ClNO₂S
• Molecular Weight: 381.883
• Mol file: 946162-01-2.mol

Synonyms:4-methyl-N-(4-chloro-2-phenylethynyl-phenyl)-benzenesulfonamide

Chemical Property of 4-methyl-N-(4-chloro-2-phenylethynyl-phenyl)-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-methyl-N-(4-chloro-2-phenylethynyl-phenyl)-benzenesulfonamide

There total 7 articles about 4-methyl-N-(4-chloro-2-phenylethynyl-phenyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-chloro-2-(phenylethynyl)aniline (928782-97-2) + p-toluenesulfonyl chloride (98-59-9) → 4-methyl-N-(4-chloro-2-phenylethynyl-phenyl)-benzenesulfonamide (946162-01-2)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 12h;

DOI:10.1002/chem.201405695

Reference yield: 86.0%

p-chloro-o-iodoaniline (63069-48-7) + phenylacetylene (536-74-3) + p-toluenesulfonyl chloride (98-59-9) → 4-methyl-N-(4-chloro-2-phenylethynyl-phenyl)-benzenesulfonamide (946162-01-2)

Guidance literature:

p-chloro-o-iodoaniline; With bis-triphenylphosphine-palladium(II) chloride; triethylamine; for 0.25h;

phenylacetylene; With copper(l) iodide; at 20 ℃;

p-toluenesulfonyl chloride; With pyridine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/cjoc.202000701

Reference yield:

p-chloro-o-iodoaniline (63069-48-7) → 4-methyl-N-(4-chloro-2-phenylethynyl-phenyl)-benzenesulfonamide (946162-01-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CuI; triethylamine / Pd(Ph₃P)2Cl₂ / 20 °C

2: pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane;

DOI:10.1021/jo070681h

upstream raw materials:

4-chloro-2-(phenylethynyl)aniline

p-toluenesulfonyl chloride

p-chloro-o-iodoaniline

phenylacetylene