2-amino-4-(3-methylphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

Base Information

• Chemical Name: 2-amino-4-(3-methylphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
• CAS No.: 414896-26-7
• Molecular Formula: C₁₇H₁₆N₂O₂
• Molecular Weight: 280.326
• Mol file: 414896-26-7.mol

Synonyms:2-amino-5-oxo-4-(m-tolyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

Chemical Property of 2-amino-4-(3-methylphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-AMINO-4-(3-METHYLPHENYL)-5-OXO-5,6,7,8-TETRAHYDRO-4H-CHROMENE-3-CARBONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-4-(3-methylphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

There total 2 articles about 2-amino-4-(3-methylphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,3-cylohexanedione (504-02-9) + m-tolyl aldehyde (620-23-5) + malononitrile (109-77-3) → 2-amino-5-oxo-4-(m-tolyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (414896-26-7)

Guidance literature:

In water; at 20 ℃; for 0.75h; Green chemistry;

DOI:10.1007/s11164-017-3151-9

Reference yield:

1,3-Cyclohexanedione (30182-67-3) + m-tolyl aldehyde (620-23-5) + malononitrile (109-77-3) → 2-amino-5-oxo-4-(m-tolyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (414896-26-7)

Guidance literature:

With dmap; at 150 ℃; Microwave irradiation;

DOI:10.1016/j.ejmech.2017.03.002

Reference yield:

2-amino-5-oxo-4-(m-tolyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (414896-26-7) → 4-(4-methoxyaniline)-5-(3-methylphenyl)-8,9-dihydro-5H-chromeno[2,3-d]pyrimidin-6(7H)-one

Guidance literature:

Multi-step reaction with 2 steps

1: 20 °C

2: acetic acid / Reflux

With acetic acid;

DOI:10.1016/j.ejmech.2017.03.002

upstream raw materials:

1,3-Cyclohexanedione

m-tolyl aldehyde

malononitrile

1,3-cylohexanedione