5-(3-p-toluensulfonyl propyl)-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3-(2H)-one

Base Information

Chemical Name:5-(3-p-toluensulfonyl propyl)-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3-(2H)-one
CAS No.:171191-89-2
Molecular Formula:C₂₃H₂₇NO₄S
Molecular Weight:413.538
Hs Code.:

5-(3-p-toluensulfonyl propyl)-1,4,4a,5,6,10b-hexahydrobenzo<f>quinolin-3-(2H)-one

Synonyms:5-(3-p-toluensulfonyl propyl)-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3-(2H)-one

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Chemical Property of 5-(3-p-toluensulfonyl propyl)-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3-(2H)-one

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Technology Process of 5-(3-p-toluensulfonyl propyl)-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3-(2H)-one

There total 3 articles about 5-(3-p-toluensulfonyl propyl)-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3-(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

: 98-59-9
p-toluenesulfonyl chloride

: 171191-88-1
5-(3-hydroxypropyl)-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3-(2H)-one

: 171191-89-2
5-(3-p-toluensulfonyl propyl)-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3-(2H)-one

Guidance literature:: With pyridine; at 0 ℃;
DOI:10.1080/00397919508011436

Reference yield:

: 171191-86-9
5-allyl-1,4,5,6-tetrahydrobenzoquinolin-3-(2H)-one

: 171191-89-2
5-(3-p-toluensulfonyl propyl)-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3-(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 66.7 percent / Et₃SiH, CF₃COOH / CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) disiamyl borane, 2.) 3N aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, 0 deg C, 1.5 h, 2.) THF, 0 deg C, 1 h

3: 96.8 percent / pyridine / 0 °C

With pyridine; triethylsilane; sodium hydroxide; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane; trifluoroacetic acid; In dichloromethane;
DOI:10.1080/00397919508011436

Reference yield:

: 171191-87-0
5-allyl-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3-(2H)-one

: 171191-89-2
5-(3-p-toluensulfonyl propyl)-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3-(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) disiamyl borane, 2.) 3N aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, 0 deg C, 1.5 h, 2.) THF, 0 deg C, 1 h

2: 96.8 percent / pyridine / 0 °C

With pyridine; sodium hydroxide; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane;
DOI:10.1080/00397919508011436