3-{7-[(1-azabicyclo[2.2.2]oct-4-ylmethyl)amino]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl}phenol

Base Information

Chemical Name:3-{7-[(1-azabicyclo[2.2.2]oct-4-ylmethyl)amino]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl}phenol
CAS No.:1186331-99-6
Molecular Formula:C₂₅H₂₆N₆O
Molecular Weight:426.521
Hs Code.:

Synonyms:3-{7-[(1-azabicyclo[2.2.2]oct-4-ylmethyl)amino]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl}phenol

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Chemical Property of 3-{7-[(1-azabicyclo[2.2.2]oct-4-ylmethyl)amino]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl}phenol

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Technology Process of 3-{7-[(1-azabicyclo[2.2.2]oct-4-ylmethyl)amino]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl}phenol

There total 9 articles about 3-{7-[(1-azabicyclo[2.2.2]oct-4-ylmethyl)amino]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1186334-45-1
N-(1-aza-bicyclo[2.2.2]oct-4-ylmethyl)-[3-(3-methoxy-phenyl)-2-pyridin-4-yl-pyrazolo[1,5,a]pyrimidin-7-yl]-amine

: 1186331-99-6
3-{7-[(1-azabicyclo[2.2.2]oct-4-ylmethyl)amino]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl}phenol

Guidance literature:: N-(1-aza-bicyclo[2.2.2]oct-4-ylmethyl)-[3-(3-methoxy-phenyl)-2-pyridin-4-yl-pyrazolo[1,5,a]pyrimidin-7-yl]-amine; With pyridine hydrochloride; at 205 ℃; for 1h;

With ammonium hydroxide;

Reference yield:

: 1134598-69-8
2-(3-methoxyphenyl)-3-oxo-3-pyridin-4-yl-propionitrile

: 1186331-99-6
3-{7-[(1-azabicyclo[2.2.2]oct-4-ylmethyl)amino]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl}phenol

Guidance literature:: Multi-step reaction with 8 steps

1: trichlorophosphate / 18 h / 80 °C

2: hydrazine hydrate / ethanol / 6.5 h / Reflux

3: acetic acid / 2.5 h / Reflux

4: sodium hydroxide / 4 h / Reflux

5: Dowtherm / 0.75 h / 250 °C

6: N,N-diethylaniline; trichlorophosphate / 2 h / 110 °C

7: N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 5 °C

8: pyridine hydrochloride / 1 h / 205 °C

With pyridine hydrochloride; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In ethanol; Dowtherm; acetonitrile;

Reference yield:

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 1186331-99-6
3-{7-[(1-azabicyclo[2.2.2]oct-4-ylmethyl)amino]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl}phenol

Guidance literature:: Multi-step reaction with 9 steps

1: ethanol; sodium / 4 h / 45 °C / Reflux

2: trichlorophosphate / 18 h / 80 °C

3: hydrazine hydrate / ethanol / 6.5 h / Reflux

4: acetic acid / 2.5 h / Reflux

5: sodium hydroxide / 4 h / Reflux

6: Dowtherm / 0.75 h / 250 °C

7: N,N-diethylaniline; trichlorophosphate / 2 h / 110 °C

8: N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 5 °C

9: pyridine hydrochloride / 1 h / 205 °C

With ethanol; pyridine hydrochloride; sodium; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In ethanol; Dowtherm; acetonitrile;