((1S,2S)-2-Benzyloxy-1-hydroxy-3-methyl-butyl)-phosphonic acid dimethyl ester

Base Information

Chemical Name:((1S,2S)-2-Benzyloxy-1-hydroxy-3-methyl-butyl)-phosphonic acid dimethyl ester
CAS No.:160423-21-2
Molecular Formula:C₁₄H₂₃O₅P
Molecular Weight:302.307
Hs Code.:

Synonyms:((1S,2S)-2-Benzyloxy-1-hydroxy-3-methyl-butyl)-phosphonic acid dimethyl ester

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Chemical Property of ((1S,2S)-2-Benzyloxy-1-hydroxy-3-methyl-butyl)-phosphonic acid dimethyl ester

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Technology Process of ((1S,2S)-2-Benzyloxy-1-hydroxy-3-methyl-butyl)-phosphonic acid dimethyl ester

There total 1 articles about ((1S,2S)-2-Benzyloxy-1-hydroxy-3-methyl-butyl)-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 67217-06-5
tert-butyldimethylsilyl dimethyl phosphite

: 110840-39-6
(S)-(+)-2-(benzyloxy)-3-methylbutanal

: 160423-21-2
((1S,2S)-2-Benzyloxy-1-hydroxy-3-methyl-butyl)-phosphonic acid dimethyl ester

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -78 ℃; for 1.5h;
DOI:10.1021/jo00104a064

Reference yield: 65.0%

: 160423-21-2
((1S,2S)-2-Benzyloxy-1-hydroxy-3-methyl-butyl)-phosphonic acid dimethyl ester

: 160423-12-1
((1R,2S)-1-Azido-2-benzyloxy-3-methyl-butyl)-phosphonic acid dimethyl ester

Guidance literature:: With tris-(2-chloro-ethyl)-amine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; benzene; 1.) -35 deg C, 30 min, 2.) r.t., 12 h;
DOI:10.1021/jo00104a064

Reference yield:

: 160423-21-2
((1S,2S)-2-Benzyloxy-1-hydroxy-3-methyl-butyl)-phosphonic acid dimethyl ester

: ((1R,2S)-2-Benzyloxy-1-tert-butoxycarbonylamino-3-methyl-butyl)-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / HN₃, diethyl azodicarboxylate, Ph₃P / tetrahydrofuran; benzene / 1.) -35 deg C, 30 min, 2.) r.t., 12 h

2: 83 percent / H₂ / 10percent Pd/C / ethyl acetate / 12 h / Ambient temperature

With tris-(2-chloro-ethyl)-amine; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jo00104a064