ethyl 4-(1-(4-bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-3-methylbutanoate

Base Information

Chemical Name:ethyl 4-(1-(4-bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-3-methylbutanoate
CAS No.:185737-64-8
Molecular Formula:C₂₄H₂₈BrNO₃
Molecular Weight:458.395
Hs Code.:

Synonyms:ethyl 4-(1-(4-bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-3-methylbutanoate

Suppliers and Price of ethyl 4-(1-(4-bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-3-methylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-(1-(4-bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-3-methylbutanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 4-(1-(4-bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-3-methylbutanoate

There total 6 articles about ethyl 4-(1-(4-bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 185737-63-7
ethyl 4-(1-(4-bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-2(E)-butenoate

: ammonium chloride

: 185737-64-8
ethyl 4-(1-(4-bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-3-methylbutanoate

Guidance literature:: With CuI; methyllithium; In tetrahydrofuran; diethyl ether; hexane; ethyl acetate;

Reference yield:

: 917-54-4
methyllithium

: 176045-82-2
(E)-4-[1-(4-Bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-but-2-enoic acid ethyl ester

: 185737-64-8
ethyl 4-(1-(4-bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-3-methylbutanoate

Guidance literature:: With copper(l) iodide; chloro-trimethyl-silane; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;
DOI:10.1016/0960-894X(96)00101-1

Reference yield:

: 539-88-8
4-oxopentanoic acid ethyl ester

: 185737-64-8
ethyl 4-(1-(4-bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) HOAc, 2.) HCl / 1.) toluene, room temp., 2.) EtOH, reflux

2: 1.) DIBALH, 2.) tartaric acid / 1.) CH₂Cl₂, toluene, -100 deg C, 2.) MeOH

3: 92 percent / toluene / 80 °C

4: CuI, TMSCl / diethyl ether; tetrahydrofuran / -78 - 20 °C

With hydrogenchloride; copper(l) iodide; chloro-trimethyl-silane; diisobutylaluminium hydride; acetic acid; tartaric acid; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1016/0960-894X(96)00101-1