D-N-(tert-butoxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine

Base Information

• Chemical Name: D-N-(tert-butoxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine
• CAS No.: 123004-79-5
• Molecular Formula: C₂₆H₄₀N₂O₉
• Molecular Weight: 524.612

Synonyms:D-N-(tert-butoxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine

Chemical Property of D-N-(tert-butoxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine

Chemical Property:

Purity/Quality:

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Technology Process of D-N-(tert-butoxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine

There total 5 articles about D-N-(tert-butoxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → D-N-(tert-butoxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine (123004-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / 1N NaOH / H₂O; dioxane / 4 h / Ambient temperature

2: potassium hydride / 1.) DMF, RT, 10 min, 2.) DMF, RT, 3 h

With sodium hydroxide; potassium hydride; In 1,4-dioxane; water;

DOI:10.1021/ja00158a040

Reference yield:

D-4-hydroxyphenylglycine (22818-40-2) → D-N-(tert-butoxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine (123004-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / 1N NaOH / H₂O; dioxane / 4 h / Ambient temperature

2: potassium hydride / 1.) DMF, RT, 10 min, 2.) DMF, RT, 3 h

With sodium hydroxide; potassium hydride; In 1,4-dioxane; water;

DOI:10.1021/ja00158a040

Reference yield:

tert-butyl D-N-(tert-butoxycarbonyl)homoserinate (110207-49-3) → D-N-(tert-butoxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine (123004-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / carbon tetrabromide, triphenylphosphine / CH₂Cl₂ / 2 h / Ambient temperature

2: potassium hydride / 1.) DMF, RT, 10 min, 2.) DMF, RT, 3 h

With carbon tetrabromide; potassium hydride; triphenylphosphine; In dichloromethane;

DOI:10.1021/ja00158a040

upstream raw materials:

tert-butyl D-2-<(tert-butoxycarbonyl)amino>-4-bromobutyrate

N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine

di-tert-butyl dicarbonate

D-4-hydroxyphenylglycine

Downstream raw materials:

(-)-nocardicin C

(R)-2-tert-Butoxycarbonylamino-4-[4-((R)-tert-butoxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-butyric acid tert-butyl ester

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