-<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<<2-phenyl-2-<<(1H-1,2,4-triazol-5-ylthio)acetyl>amino>ethyl>amino>ethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester

Base Information

• Chemical Name: -<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<<2-phenyl-2-<<(1H-1,2,4-triazol-5-ylthio)acetyl>amino>ethyl>amino>ethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester
• CAS No.: 141956-55-0
• Molecular Formula: C₃₅H₄₁N₇O₄S
• Molecular Weight: 655.821

Synonyms:-<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<<2-phenyl-2-<<(1H-1,2,4-triazol-5-ylthio)acetyl>amino>ethyl>amino>ethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester

Chemical Property of -<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<<2-phenyl-2-<<(1H-1,2,4-triazol-5-ylthio)acetyl>amino>ethyl>amino>ethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester

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Technology Process of -<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<<2-phenyl-2-<<(1H-1,2,4-triazol-5-ylthio)acetyl>amino>ethyl>amino>ethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester

There total 3 articles about -<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<<2-phenyl-2-<<(1H-1,2,4-triazol-5-ylthio)acetyl>amino>ethyl>amino>ethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

-<2-<<2-<(2-bromoacetyl)amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.13,7>dec-2-yl ester (141956-48-1) + 1H-1,2,4-triazole-5-thiol (3179-31-5) → -<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<<2-phenyl-2-<<(1H-1,2,4-triazol-5-ylthio)acetyl>amino>ethyl>amino>ethyl>carbamic acid tricyclo<3.3.1.13,7>dec-2-yl ester (141956-55-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1021/jm00092a007

Reference yield:

tricyclo<3.3.1.13,7>dec-2-yl *,R*)>-<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate (130406-64-3) → -<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<<2-phenyl-2-<<(1H-1,2,4-triazol-5-ylthio)acetyl>amino>ethyl>amino>ethyl>carbamic acid tricyclo<3.3.1.13,7>dec-2-yl ester (141956-55-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) pentafluorophenol (PFP), N,N'-dicyclohexylcarbodiimide (DCC) / 1.) EtOAc, RT, 2 h, 2.) EtOAc, RT, overnight

2: 90 percent / Et₃N / tetrahydrofuran / 3 h / Ambient temperature

With 2,3,4,5,6-pentafluorophenol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1021/jm00092a007

Reference yield:

tricyclo<3.3.1.13,7>dec-2-yl *,R*)>-<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate (130406-64-3) + (2H-[1,2,4]-triazol-3-ylsulfanyl)-acetic acid (24127-58-0) → -<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<<2-phenyl-2-<<(1H-1,2,4-triazol-5-ylthio)acetyl>amino>ethyl>amino>ethyl>carbamic acid tricyclo<3.3.1.13,7>dec-2-yl ester (141956-55-0)

Guidance literature:

With 2,3,4,5,6-pentafluorophenol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) DMF, RT, 3 h, 2.) DMF, RT, overnight;

DOI:10.1021/jm00092a007

upstream raw materials:

tricyclo<3.3.1.1^3,7>dec-2-yl *,R^*)>-<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate

(2H-[1,2,4]-triazol-3-ylsulfanyl)-acetic acid

-<2-<<2-<(2-bromoacetyl)amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester

1H-1,2,4-triazole-5-thiol

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