2-[(2-Amino-4-chlorophenyl)thio]benzenemethanol

Base Information

Chemical Name:2-[(2-Amino-4-chlorophenyl)thio]benzenemethanol
CAS No.:58733-48-5
Molecular Formula:C₁₃H₁₂ClNOS
Molecular Weight:265.763
Hs Code.:
DSSTox Substance ID:DTXSID401241716

Synonyms:DTXSID401241716;2-[(2-Amino-4-chlorophenyl)thio]benzenemethanol;58733-48-5

Suppliers and Price of 2-[(2-Amino-4-chlorophenyl)thio]benzenemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-[(2-Amino-4-chlorophenyl)thio]benzenemethanol

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:265.0328129
Heavy Atom Count:17
Complexity:242

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)CO)SC2=C(C=C(C=C2)Cl)N

Technology Process of 2-[(2-Amino-4-chlorophenyl)thio]benzenemethanol

There total 5 articles about 2-[(2-Amino-4-chlorophenyl)thio]benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 167996-98-7
2-(2-amino-4-chlorophenylsulfanyl)benzoic acid

: 58733-48-5
2-(2-amino-4-chlorophenylsulfanyl)methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h;
DOI:10.1021/jm000079i

Reference yield:

: 126395-03-7
2-(4-chloro-2-nitrophenylsulfanyl)benzoic acid

: 58733-48-5
2-(2-amino-4-chlorophenylsulfanyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / N₂H₄*H₂O; FeCl₃ / ethanol / 26 h / Heating

2: 77 percent / LiAlH₄ / tetrahydrofuran / 1 h

With lithium aluminium tetrahydride; iron(III) chloride; hydrazine hydrate; In tetrahydrofuran; ethanol; 1: Reduction / 2: Reduction;
DOI:10.1021/jm000079i

Reference yield:

: 147-93-3
Thiosalicylic acid

: 58733-48-5
2-(2-amino-4-chlorophenylsulfanyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / K₂CO₃; Cu / dimethylformamide / 36 h / 65 °C

2: 45 percent / N₂H₄*H₂O; FeCl₃ / ethanol / 26 h / Heating

3: 77 percent / LiAlH₄ / tetrahydrofuran / 1 h

With lithium aluminium tetrahydride; iron(III) chloride; copper; potassium carbonate; hydrazine hydrate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 1: Condensation / 2: Reduction / 3: Reduction;
DOI:10.1021/jm000079i