tert-butyl 4-(5-{[(4-nitro-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}pyridin-2-yl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(5-{[(4-nitro-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}pyridin-2-yl)piperazine-1-carboxylate
CAS No.:936755-57-6
Molecular Formula:C₂₄H₂₇N₇O₅
Molecular Weight:493.522
Hs Code.:

Synonyms:tert-butyl 4-(5-{[(4-nitro-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}pyridin-2-yl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(5-{[(4-nitro-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}pyridin-2-yl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(5-{[(4-nitro-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}pyridin-2-yl)piperazine-1-carboxylate

There total 4 articles about tert-butyl 4-(5-{[(4-nitro-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}pyridin-2-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 701917-04-6
3-amino-4-nitro-1-phenyl-1H-pyrazole

: 201809-22-5
2-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}pyridin-5-carboxylic acid

: 936755-57-6
tert-butyl 4-(5-{[(4-nitro-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}pyridin-2-yl)piperazine-1-carboxylate

Guidance literature:: With (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 17h;

Reference yield:

: 98-80-6
phenylboronic acid

: 936755-57-6
tert-butyl 4-(5-{[(4-nitro-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}pyridin-2-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / copper diacetate / dichloromethane / 48 h / 20 °C

2.1: potassium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

3.1: triethylamine; diphenylphosphoryl azide / 1,3-dioxane; tert-butyl alcohol / 16 h / Heating / reflux

3.2: 16 h / 20 °C

4.1: sodium hydride; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide; mineral oil / 17 h / 20 °C

With pyridine; potassium hydroxide; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diphenylphosphoryl azide; water; sodium hydride; triethylamine; copper diacetate; In tetrahydrofuran; 1,3-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

Reference yield:

: 701917-02-4
4-nitro-1-phenyl-1H-pyrazole-3-carboxylic acid methyl ester

: 936755-57-6
tert-butyl 4-(5-{[(4-nitro-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}pyridin-2-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

2.1: triethylamine; diphenylphosphoryl azide / 1,3-dioxane; tert-butyl alcohol / 16 h / Heating / reflux

2.2: 16 h / 20 °C

3.1: sodium hydride; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide; mineral oil / 17 h / 20 °C

With potassium hydroxide; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diphenylphosphoryl azide; water; sodium hydride; triethylamine; In tetrahydrofuran; 1,3-dioxane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;