5-(1-benzylpiperidin-4-yl)-2-(5-methanesulfonylbenzofuran-2-yl)pyridine

Base Information

Chemical Name:5-(1-benzylpiperidin-4-yl)-2-(5-methanesulfonylbenzofuran-2-yl)pyridine
CAS No.:1268816-32-5
Molecular Formula:C₂₆H₂₆N₂O₃S
Molecular Weight:446.57
Hs Code.:

Synonyms:5-(1-benzylpiperidin-4-yl)-2-(5-methanesulfonylbenzofuran-2-yl)pyridine

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Chemical Property of 5-(1-benzylpiperidin-4-yl)-2-(5-methanesulfonylbenzofuran-2-yl)pyridine

Chemical Property:

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Technology Process of 5-(1-benzylpiperidin-4-yl)-2-(5-methanesulfonylbenzofuran-2-yl)pyridine

There total 8 articles about 5-(1-benzylpiperidin-4-yl)-2-(5-methanesulfonylbenzofuran-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1268816-31-4
5-(1-benzylpiperidin-4-yl)-2-(5-bromobenzofuran-2-yl)pyridine

: 20277-69-4
sodium methansulfinate

: 1268816-32-5
5-(1-benzylpiperidin-4-yl)-2-(5-methanesulfonylbenzofuran-2-yl)pyridine

Guidance literature:: With copper(I) triflate-benzene; N,N`-dimethylethylenediamine; In dimethyl sulfoxide; at 130 ℃; Inert atmosphere;

Reference yield:

: 1206968-55-9
Benzyl 4-[2-(hydroxymethyl) pyridin-5-yl]-3, 6-dihydro-2H-pyridine-1-carboxylate

: 1268816-32-5
5-(1-benzylpiperidin-4-yl)-2-(5-methanesulfonylbenzofuran-2-yl)pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C / 760.05 Torr

2.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

3.1: triethylamine / chloroform / 3 h / 20 °C / Cooling with ice

4.1: potassium carbonate; potassium iodide / acetonitrile / Reflux

5.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

5.2: 110 °C

5.3: Reflux

6.1: N,N`-dimethylethylenediamine; copper(I) triflate-benzene / dimethyl sulfoxide / 130 °C / Inert atmosphere

With copper(I) triflate-benzene; hydrogen; potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; chloroform; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 286961-15-7
benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1 (2H)-pyridinecarboxylate

: 1268816-32-5
5-(1-benzylpiperidin-4-yl)-2-(5-methanesulfonylbenzofuran-2-yl)pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 2.5 h / 90 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C / 760.05 Torr

3.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

4.1: triethylamine / chloroform / 3 h / 20 °C / Cooling with ice

5.1: potassium carbonate; potassium iodide / acetonitrile / Reflux

6.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

6.2: 110 °C

6.3: Reflux

7.1: N,N`-dimethylethylenediamine; copper(I) triflate-benzene / dimethyl sulfoxide / 130 °C / Inert atmosphere

With copper(I) triflate-benzene; hydrogen; potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; N,N`-dimethylethylenediamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 1.1: Suzuki Coupling;