2'-O-Acetyl-O⁶-benzyl-3',5'-bis-O-(2,4-dichlorobenzyl)-N²-isobutyrylguanosin

Base Information

Chemical Name:2'-O-Acetyl-O⁶-benzyl-3',5'-bis-O-(2,4-dichlorobenzyl)-N²-isobutyrylguanosin
CAS No.:163760-18-7
Molecular Formula:C₃₇H₃₅Cl₄N₅O₇
Molecular Weight:803.526
Hs Code.:

2'-O-Acetyl-O<sup>6</sup>-benzyl-3',5'-bis-O-(2,4-dichlorobenzyl)-N<sup>2</sup>-isobutyrylguanosin

Synonyms:2'-O-Acetyl-O⁶-benzyl-3',5'-bis-O-(2,4-dichlorobenzyl)-N²-isobutyrylguanosin

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Chemical Property of 2'-O-Acetyl-O⁶-benzyl-3',5'-bis-O-(2,4-dichlorobenzyl)-N²-isobutyrylguanosin

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Technology Process of 2'-O-Acetyl-O⁶-benzyl-3',5'-bis-O-(2,4-dichlorobenzyl)-N²-isobutyrylguanosin

There total 7 articles about 2'-O-Acetyl-O⁶-benzyl-3',5'-bis-O-(2,4-dichlorobenzyl)-N²-isobutyrylguanosin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 163760-20-1
O⁶-Benzyl-N²-isobutyrylguanin

: 163759-42-0
Methyl-2-O-acetyl-3,5-bis-O-(2,4-dichlorobenzyl)-α-D-ribofuranosid

: 163760-18-7
2'-O-Acetyl-O⁶-benzyl-3',5'-bis-O-(2,4-dichlorobenzyl)-N²-isobutyrylguanosin

Guidance literature:: With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; In toluene; at 100 ℃; for 3h;
DOI:10.1002/hlca.19950780219

Reference yield:

: 50-69-1
D-ribose

: 163760-18-7
2'-O-Acetyl-O⁶-benzyl-3',5'-bis-O-(2,4-dichlorobenzyl)-N²-isobutyrylguanosin

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) cc. H₂SO₄, 2.) NaH / 1.) 4 deg C, 16 h, 2.) DMF, 40 deg C

2: 125.9 g / SnCl₄ / CH₂Cl₂ / 35 h / 3 °C

3: pyridine, 4-(dimethylamino)-pyridine / 17 h

4: 47 percent / BSA, TfOSiMe₃ / toluene / 3 h / 100 °C

With pyridine; benzenesulfonamide; dmap; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; tin(IV) chloride; sodium hydride; In dichloromethane; toluene;
DOI:10.1002/hlca.19950780219

Reference yield:

: 94-99-5
2,4-Dichlorobenzyl chloride

: 163760-18-7
2'-O-Acetyl-O⁶-benzyl-3',5'-bis-O-(2,4-dichlorobenzyl)-N²-isobutyrylguanosin

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) cc. H₂SO₄, 2.) NaH / 1.) 4 deg C, 16 h, 2.) DMF, 40 deg C

2: 125.9 g / SnCl₄ / CH₂Cl₂ / 35 h / 3 °C

3: pyridine, 4-(dimethylamino)-pyridine / 17 h

4: 47 percent / BSA, TfOSiMe₃ / toluene / 3 h / 100 °C

With pyridine; benzenesulfonamide; dmap; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; tin(IV) chloride; sodium hydride; In dichloromethane; toluene;
DOI:10.1002/hlca.19950780219