4-{(S)-5-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-butyric acid

Base Information

Chemical Name:4-{(S)-5-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-butyric acid
CAS No.:128684-50-4
Molecular Formula:C₅₀H₆₀N₆O₈
Molecular Weight:873.062
Hs Code.:

4-{(S)-5-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-butyric acid

Synonyms:4-{(S)-5-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-butyric acid

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Chemical Property of 4-{(S)-5-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-butyric acid

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Technology Process of 4-{(S)-5-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-butyric acid

There total 1 articles about 4-{(S)-5-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 128684-49-1
((R)-1-{(S)-5-Amino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester; hydrochloride

: 2959-96-8
2-phenylglutaric anhydride

: 128684-50-4
4-{(S)-5-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-butyric acid

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1021/jm00171a034

Reference yield: 95.0%

: 128684-50-4
4-{(S)-5-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-butyric acid

: 128684-24-2
4-{(S)-5-((R)-2-Amino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-butyric acid

Guidance literature:: With hydrogen; ammonium formate; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00171a034

Reference yield:

: 128684-50-4
4-{(S)-5-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-butyric acid

: 128684-16-2
(2R,5S)-2-Benzyl-3,11,15-trioxo-14-phenyl-1,4,10-triaza-cyclopentadecane-5-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / H₂, ammonium formate / 10percent Pd-C / aq. ethanol

2: 5 percent / diphenyl phosphorazidate, NaHCO₃ / dimethylformamide / 4 °C

With diphenyl phosphoryl azide; hydrogen; ammonium formate; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a034