(R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate
CAS No.:937248-77-6
Molecular Formula:C₃₄H₃₉N₅O₂
Molecular Weight:549.716
Hs Code.:

Synonyms:(R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

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Chemical Property of (R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

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Technology Process of (R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

There total 6 articles about (R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 937247-96-6
(R)-tert-butyl 1-(4-ethylbenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate

: 3538-68-9
3-phenylpropanehydrazide

: 937248-77-6
(R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

Guidance literature:: With mercury(II) diacetate; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1021/jm0704550

Reference yield:

: 956489-60-4
(R)-tert-butyl 1-(4-ethylbenzylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamate

: 937248-77-6
(R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: Lawesson's reagent / 1,2-dimethoxy-ethane / 2 h / 85 °C

2: mercury(II) acetate / tetrahydrofuran / 48 h / 20 °C

With Lawessons reagent; mercury(II) diacetate; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1021/jm070024h

Reference yield:

: 103-25-3
3-phenylpropanoic acid methyl ester

: 937248-77-6
(R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / hydrazine monohydrate / ethanol / Heating

2: mercury(II) acetate / tetrahydrofuran / 48 h / 20 °C

With mercury(II) diacetate; hydrazine hydrate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm070024h