2-(4-pyridinyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 2-(4-pyridinyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
• CAS No.: 357618-22-5
• Molecular Formula: C₁₅H₁₃N₃OS
• Molecular Weight: 283.354
• Mol file: 357618-22-5.mol

Synonyms:2-pyridin-4-yl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-ol

Chemical Property of 2-(4-pyridinyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-pyridinyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

There total 5 articles about 2-(4-pyridinyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

pyridine-4-carbonitrile (100-48-1) + ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → 2-(pyridin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (357618-22-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;

DOI:10.2174/1570180814666171027161555

Reference yield: 83.0%

pyridine-4-carbonitrile (100-48-1) + ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → 2-(pyridin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (357618-22-5) + C17H17N3OS

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; Sonication; Sealed tube;

DOI:10.1016/j.bmc.2020.115480

Reference yield: 65.0%

pyridine-4-carbaldehyde (872-85-5) + 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (4815-28-5) → 2-(pyridin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (357618-22-5)

Guidance literature:

With sulfur; In neat (no solvent); at 140 ℃; for 2.5h;

DOI:10.1515/mgmc-2017-0038

upstream raw materials:

pyridine-4-carbonitrile

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

cyclohexanone

pyridine-4-carbaldehyde

Downstream raw materials:

2,4,6-triisopropylbenzenesulfonic acid 2-pyridin-4-yl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl ester

(R)-3-phenyl-N₁-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propane-1,2-diamine

(S)-3-phenyl-N₁-(2-(pyridin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propane-1,2-diamine

(S)-1-(4-methoxybenzyl)-2-(2-pyridin-4-yl-5 ,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yloxy)ethylamine