Technology Process of 2-(methylthiomethoxy)-2-phenylacetaldehyde
There total 3 articles about 2-(methylthiomethoxy)-2-phenylacetaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
((2,2-diethoxy-1-phenylethoxy)methyl)(methyl)sulfane;
With
2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate;
In
dichloromethane;
at 0 ℃;
for 6h;
Inert atmosphere;
With
water;
In
dichloromethane;
at 20 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/ol1030662
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride; sodium iodide / 1,2-dimethoxyethane; paraffin oil / 1 h / 20 °C / Inert atmosphere
2.2: 18 h / Inert atmosphere
3.1: 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 6 h / 0 °C / Inert atmosphere
3.2: 0.5 h / 20 °C / Inert atmosphere
With
2,6-dimethylpyridine; sodium tetrahydroborate; trimethylsilyl trifluoromethanesulfonate; sodium hydride; sodium iodide;
In
methanol; 1,2-dimethoxyethane; dichloromethane; paraffin oil;
DOI:10.1021/ol1030662
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride; sodium iodide / 1,2-dimethoxyethane; paraffin oil / 1 h / 20 °C / Inert atmosphere
1.2: 18 h / Inert atmosphere
2.1: 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 6 h / 0 °C / Inert atmosphere
2.2: 0.5 h / 20 °C / Inert atmosphere
With
2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; sodium hydride; sodium iodide;
In
1,2-dimethoxyethane; dichloromethane; paraffin oil;
DOI:10.1021/ol1030662
