Technology Process of 1-ethyl-8-fluoro-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one
There total 8 articles about 1-ethyl-8-fluoro-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-ethyl-8-fluoro-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid;
With
triethylamine; isobutyl chloroformate;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
Inert atmosphere;
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at -40 ℃;
for 1.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / 5 h / 120 °C / Inert atmosphere
2.1: boron tribromide / dichloromethane / -78 - 25 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C / Inert atmosphere
4.1: water; potassium hydroxide / methanol / 3 h / 90 °C / Inert atmosphere
5.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
5.2: 1.5 h / -40 °C / Inert atmosphere
With
water; boron tribromide; potassium carbonate; triethylamine; potassium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: platinum(IV) oxide; hydrogen / ethanol / 0.5 h / Inert atmosphere
2.1: ethanol / 1 h / 80 °C / Inert atmosphere
3.1: 0.67 h / 250 °C / Inert atmosphere
4.1: potassium carbonate / 5 h / 120 °C / Inert atmosphere
5.1: boron tribromide / dichloromethane / -78 - 25 °C / Inert atmosphere
5.2: Inert atmosphere
6.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C / Inert atmosphere
7.1: water; potassium hydroxide / methanol / 3 h / 90 °C / Inert atmosphere
8.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
8.2: 1.5 h / -40 °C / Inert atmosphere
With
platinum(IV) oxide; water; hydrogen; boron tribromide; potassium carbonate; triethylamine; potassium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
