N-(2-methyl-5-(4-(morpholinomethyl)-3-(trifluoromethyl)benzamido)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

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Chemical Name:N-(2-methyl-5-(4-(morpholinomethyl)-3-(trifluoromethyl)benzamido)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
CAS No.:1086422-84-5
Molecular Formula:C₂₈H₂₆F₃N₅O₃
Molecular Weight:537.541
Hs Code.:

Synonyms:N-(2-methyl-5-(4-(morpholinomethyl)-3-(trifluoromethyl)benzamido)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

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Chemical Property of N-(2-methyl-5-(4-(morpholinomethyl)-3-(trifluoromethyl)benzamido)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

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Technology Process of N-(2-methyl-5-(4-(morpholinomethyl)-3-(trifluoromethyl)benzamido)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

There total 11 articles about N-(2-methyl-5-(4-(morpholinomethyl)-3-(trifluoromethyl)benzamido)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1086422-84-5
N-(2-methyl-5-(4-(morpholinomethyl)-3-(trifluoromethyl)benzamido)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: sec.-butyllithium / tetrahydrofuran / 0.75 h / -78 °C

2.2: 2 h

2.3: pH 2

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5.1: sodium hydroxide; water / methanol / 4 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 760.05 Torr

7.1: hydrogenchloride / tetrahydrofuran; methanol; water / 50 - 60 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.03 h / 20 °C

8.2: 20 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; oxalyl dichloride; water; hydrogen; sec.-butyllithium; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 934020-34-5
4-morpholin-4-ylmethyl-3-trifluoromethyl-benzoic acid

: 1086423-50-8
1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid (5-amino-2-methyl-phenyl)-amide

: 1086422-84-5
N-(2-methyl-5-(4-(morpholinomethyl)-3-(trifluoromethyl)benzamido)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

Guidance literature:: 4-morpholin-4-ylmethyl-3-trifluoromethyl-benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.0333333h;

1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid (5-amino-2-methyl-phenyl)-amide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 630410-29-6
(4-methyl-3-nitro-phenyl)-carbamic acid tert-butyl ester

: 1086422-84-5
N-(2-methyl-5-(4-(morpholinomethyl)-3-(trifluoromethyl)benzamido)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 3102.97 Torr

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3.1: sodium hydroxide; water / methanol / 4 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 760.05 Torr

5.1: hydrogenchloride / tetrahydrofuran; methanol; water / 50 - 60 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.03 h / 20 °C

6.2: 20 °C

With hydrogenchloride; sodium hydroxide; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;